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Correspondence
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Volume 335:61-62 July 4, 1996 Number 1
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Massive Infiltration of the Skin by HIV-Specific Cytotoxic CD8+ T Cells

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To the Editor: A 32-year-old man infected with the human immunodeficiency virus (HIV) since 1987 presented in May 1993 with scaly, erythematous skin plaques. His CD4 count was 403 per cubic millimeter. In June 1994, he was admitted because of a pruriginous erythroderma, with infiltrated, photosensitive lesions and a palmoplantar keratoderma. Examination revealed enlarged axillary and inguinocrural lymph nodes.

The laboratory findings included 1400 eosinophils per cubic millimeter, 2820 lymphocytes per cubic millimeter (89 percent were CD8+ T cells), and the presence of Sézary cells (300 per cubic millimeter). Histologic studies showed a lymphoid infiltrate with epidermotropism and microabscesses, including . . . [Full Text of this Article]

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