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Correspondence
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Volume 335:752-753 September 5, 1996 Number 10
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Occult Gastrointestinal Bleeding in Celiac Sprue

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 by Fine, K. D.
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 by Allison, J. E.
To the Editor: Dr. Fine (May 2 issue)1 concludes, on the basis of guaiac (Hemoccult) testing, that patients with celiac sprue have a high prevalence of occult gastrointestinal bleeding. A fact mentioned, but not discussed, is that the testing was performed with two different products: Hemoccult II for specimens analyzed between 1985 and 1990 and Hemoccult Sensa for specimens analyzed between 1991 and 1995. These two products have different sensitivities to peroxidase-containing materials.

In a recent large screening study comparing the performance of the two tests on the same stool samples from about 8000 subjects, 2.5 percent were positive with . . . [Full Text of this Article]

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