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Previous Volume 335:860-863 September 19, 1996 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Insulin-dependent diabetes mellitus is an autoimmune disease in which the beta cells of the islets of Langerhans are selectively destroyed.¹ In a patient with this disease, a transplanted pancreas should be as susceptible to the autoimmune process as the native pancreas. Indeed, insulin-dependent diabetes mellitus can recur in an immunocompetent or minimally immunosuppressed recipient of a pancreatic transplant from an identical twin or HLA-identical sibling.² Usually, however, the degree of immunosuppression required to prevent rejection is sufficient to prevent autoimmune damage to the pancreatic graft.³ We report on two patients who underwent pancreatic transplantation with poor HLA matching and in . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Discussion

Source Information

From the Divisions of Transplantation Surgery (G.T.), Pathology (F.P.R.), and Medicine (J.B.), Karolinska Institute, Huddinge Hospital, Huddinge, and the Department of Endocrinology, Malmö University Hospital, Malmö (G.S.) — both in Sweden.

Address reprint requests to Dr. Tydén at the Division of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, 141 86 Huddinge, Sweden.

References

This article has been cited by other articles:

• Kupfer, T. M., Crawford, M. L., Pham, K., Gill, R. G. (2005). MHC-Mismatched Islet Allografts Are Vulnerable to Autoimmune Recognition In Vivo. J. Immunol. 175: 2309-2316 [Abstract] [Full Text]  
• Nikolic, B., Takeuchi, Y., Leykin, I., Fudaba, Y., Smith, R. N., Sykes, M. (2004). Mixed Hematopoietic Chimerism Allows Cure of Autoimmune Diabetes Through Allogeneic Tolerance and Reversal of Autoimmunity. Diabetes 53: 376-383 [Abstract] [Full Text]  
• Palmer, J. P., Fleming, G. A., Greenbaum, C. J., Herold, K. C., Jansa, L. D., Kolb, H., Lachin, J. M., Polonsky, K. S., Pozzilli, P., Skyler, J. S., Steffes, M. W. (2004). C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve {beta}-Cell Function: Report of an ADA Workshop, 21-22 October 2001. Diabetes 53: 250-264 [Abstract] [Full Text]  
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• Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., Bluestone, J. A. (2002). Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus. NEJM 346: 1692-1698 [Abstract] [Full Text]  
• Bosi, E., Braghi, S., Maffi, P., Scirpoli, M., Bertuzzi, F., Pozza, G., Secchi, A., Bonifacio, E. (2001). Autoantibody Response to Islet Transplantation in Type 1 Diabetes. Diabetes 50: 2464-2471 [Abstract] [Full Text]  
• Borg, H., Gottsater, A., Landin-Olsson, M., Fernlund, P., Sundkvist, G. (2001). High Levels of Antigen-Specific Islet Antibodies Predict Future {beta}-Cell Failure in Patients with Onset of Diabetes in Adult Age. J. Clin. Endocrinol. Metab. 86: 3032-3038 [Abstract] [Full Text]  
• Wortsman, J., McConnachie, P., Tahara, K., Kohn, L. D. (1998). Thyrotropin Receptor Epitopes Recognized by Graves' Autoantibodies Developing under Immunosuppressive Therapy. J. Clin. Endocrinol. Metab. 83: 2302-2308 [Abstract] [Full Text]  
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