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Previous Volume 335:898-899 September 19, 1996 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Methotrexate is effective in the treatment of a number of chronic diseases, such as Crohn's disease,¹ but concern about long-term hepatotoxicity has limited its widespread use. Although elevated serum aminotransferase concentrations are often considered a reason for stopping methotrexate,¹ there is little information about the nature or seriousness of the elevations and little, if any, correlation between them and liver histology. We report on a patient who had transient increases in serum aminotransferase values with unchanged liver histology while receiving methotrexate for primary sclerosing cholangitis.

A 37-year-old man was referred to our center because of jaundice and . . . [Full Text of this Article]

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