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Previous Volume 335:943-951 September 26, 1996 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Recent years have brought major advances in our understanding of the molecular genetic basis of both types of multiple endocrine neoplasia (MEN), an autosomal dominant cancer syndrome. MEN type 1 (MEN-1 [designated "MEN 1" by the Second International MEN Workshop]) is the triad of parathyroid, pancreatic islet-cell, and anterior pituitary tumors.¹ Carcinoid, adrenal cortical, and lipoid tumors may also occur in MEN-1. Its susceptibility gene has been mapped but not isolated, and in some kindreds polymorphic markers that flank the gene can be used for predictive DNA testing.² MEN type 2 (MEN-2) is a syndrome of medullary thyroid carcinoma, pheochromocytoma, . . . [Full Text of this Article]

MEN-1

MEN-2

Clinical Diagnosis

Pathological Analysis

Screening

The RET Proto-Oncogene

Predictive Testing and Targeted Medical Management

Genotype–Phenotype Correlations in MEN-2 and Directed Screening

Testing for the RET Proto-Oncogene in Patients with Apparently Sporadic Medullary Thyroid Carcinoma

Testing for the RET Proto-Oncogene in Patients with Apparently Sporadic Pheochromocytoma

MEN-2 and Hirschsprung's Disease

Discussion

Source Information

From the Division of Cancer Epidemiology and Control, Dana–Farber Cancer Institute, Boston; the Department of Medicine, Harvard Medical School, Boston; and the Cancer Research Campaign, Human Cancer Genetics Research Group, University of Cambridge, Cambridge, United Kingdom.

Address reprint requests to Dr. Eng at the Dana–Farber Cancer Institute, 44 Binney St., D920C, Boston, MA 02115-6084.

References

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