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Previous Volume 335:963-965 September 26, 1996 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The transmissible spongiform encephalopathies, or prion diseases, are neurodegenerative conditions that affect both humans and animals. They are transmissible experimentally both within and between mammalian species by inoculation with infected tissues and sometimes by ingestion in food. The diseases affecting humans have traditionally been classified as Creutzfeldt–Jakob disease, Gerstmann–Sträussler–Scheinker disease, and kuru. They are rare, affecting about one person per million worldwide per year. By contrast, the prototypic spongiform encephalopathy scrapie is a relatively common, naturally occurring disease of sheep and goats, recognized for well over 200 years and occurring in many countries. Although these diseases have long been of . . . [Full Text of this Article]

References

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• Wadsworth, J. D., Hill, A. F, Beck, J. A, Collinge, J. (2003). Molecular and clinical classification of human prion disease. Br Med Bull 66: 241-254 [Abstract] [Full Text]  
• Hill, A. F., Joiner, S., Wadsworth, J. D. F., Sidle, K. C. L., Bell, J. E., Budka, H., Ironside, J. W., Collinge, J. (2003). Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain 126: 1333-1346 [Abstract] [Full Text]  
• Burkhard, P. R., Sanchez PhD, J.-C., Landis, T., Hochstrasser, D. F. (2001). CSF detection of the 14-3-3 protein in unselected patients with dementia. Neurology 56: 1528-1533 [Abstract] [Full Text]  
• Samman, I., Schulz-Schaeffer, W J, Wöhrle, J C, Sommer, A, Kretzschmar, H A, Hennerici, M (1999). Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2. J. Neurol. Neurosurg. Psychiatry 67: 678-681 [Abstract] [Full Text]  
• Bahn, M. M., Parchi, P. (1999). Abnormal Diffusion-Weighted Magnetic Resonance Images in Creutzfeldt-Jakob Disease. Arch Neurol 56: 577-583 [Abstract] [Full Text]