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Previous Volume 335:974-976 September 26, 1996 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The article by den Heijer et al. (March 21 issue)¹ supports our finding that hyperhomocysteinemia is a risk factor for deep-vein thrombosis that is independent of coexisting abnormalities of naturally occurring anticoagulants.² This important confirmation challenges the suggestion by Mandel et al., in their article in the same issue,³ that hyperhomocysteinemia increases the risk of thrombosis only if the elevation in homocysteinemia is associated with the presence of factor V Leiden.

Unlike our study of patients with early-onset deep-vein thrombosis² and their previous study of patients with recurrent deep-vein thrombosis,⁴ the current study by den Heijer et . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Martinelli, I., Battaglioli, T., Pedotti, P., Cattaneo, M., Mannucci, P. M. (2003). Hyperhomocysteinemia in cerebral vein thrombosis. Blood 102: 1363-1366 [Abstract] [Full Text]  
• Hanson, N. Q., Eckfeldt, J. H., Schwichtenberg, K., Aras, O., Tsai, M. Y. (2002). Interlaboratory Variation of Plasma Total Homocysteine Measurements: Results of Three Successive Homocysteine Proficiency Testing Surveys. Clin. Chem. 48: 1539-1545 [Abstract] [Full Text]  
• van der Griend, R., Biesma, D. H, Banga, J.-D. (2002). Postmethionine-load homocysteine determination for the diagnosis hyperhomocysteinaemia and efficacy of homocysteine lowering treatment regimens. Vasc Med 7: 29-33 [Abstract]  
• Cattaneo, M., Lombardi, R., Lecchi, A., Zighetti;, M. L., Girelli, D., Olivieri, O., Russo, C., Corrocher, R. (1999). Is the Oral Methionine Loading Test Insensitive to the Remethylation Pathway of Homocysteine?. Blood 93: 1118-1120 [Full Text]  
• Cattaneo, M., Monzani, M. L., Martinelli, I., Falcon, C. R., Mannucci, P. M., Ridker, P. M. (1998). Interrelation of Hyperhomocyst(e)inemia, Factor V Leiden, and Risk of Future Venous Thromboembolism • Response. Circulation 97: 295-296 [Full Text]  
• Moll, S., Farhadi, D., von Eckardstein, A., Assmann, G., Nygard, O., Refsum, H., Ueland, P. M., Farstad, M., Vollset, S. E., Nordrehaug, J. E. (1997). Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease. NEJM 337: 1631-1633 [Full Text]  
• D'Angelo, A., Selhub, J. (1997). Homocysteine and Thrombotic Disease. Blood 90: 1-11 [Full Text]