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Previous Volume 335:976-977 September 26, 1996 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The article by Després et al. (April 11 issue)¹ purports to demonstrate an association between hyperinsulinemia and ischemic heart disease that is independent of other known risk factors, including diabetes mellitus. However, the criteria for excluding case patients and controls with "diabetes mellitus" were not well clarified. Many of the subjects with elevated insulin levels in the fasting state may have had undiagnosed type II diabetes (non-insulin-dependent diabetes) and would have been excluded had more rigorous criteria for diabetes been applied.

It would have been valuable to measure glycosylated hemoglobin levels in all subjects to exclude those . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Lakka, H.-M., Lakka, T. A., Tuomilehto, J., Sivenius, J., Salonen, J. T. (2000). Hyperinsulinemia and the Risk of Cardiovascular Death and Acute Coronary and Cerebrovascular Events in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med 160: 1160-1168 [Abstract] [Full Text]  
• Pyorala, M., Miettinen, H., Laakso, M., Pyorala, K. (1998). Hyperinsulinemia Predicts Coronary Heart Disease Risk in Healthy Middle-aged Men : The 22-Year Follow-up Results of the Helsinki Policemen Study. Circulation 98: 398-404 [Abstract] [Full Text]