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Previous Volume 335:1070-1071 October 3, 1996 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We would like to comment on the study by Lindpaintner et al. (April 18 issue)¹ reporting no association or genetic linkage between the angiotensin-converting–enzyme (ACE) gene and left ventricular mass.

Genetic linkage between the ACE locus and left ventricular mass was investigated with the use of a sibling-pair analysis. For quantitative traits, this method is known to have a very low power, unless the locus under consideration has a very large effect (heritability of 50 percent or more).^2,3 The authors indicate that left ventricular mass has been demonstrated in the Framingham Heart Study to be . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Nakahara, K.-i., Matsushita, S., Matsuoka, H., Inamatsu, T., Nishinaga, M., Yonawa, M., Aono, T., Arai, T., Ezaki, Y., Orimo, H. (2000). Insertion/Deletion Polymorphism in the Angiotensin-Converting Enzyme Gene Affects Heart Weight. Circulation 101: 148-151 [Abstract] [Full Text]