In this issue of the Journal three important articles appear,with major implications for the clinical management of infectionwith the human immunodeficiency virus (HIV).1,2,3 Hammer etal.1 and Katzenstein et al.2 describe the clinical and virologicresults of the AIDS Clinical Trials Group Study 175 (ACTG 175),a large trial involving more than 2400 HIV-infected personswith CD4 cell counts from 200 to 500 cells per cubic millimeter.This trial clearly shows that antiretroviral therapy in suchpatients delays the progression of disease to AIDS and reducesmortality. Didanosine alone and the combination of zidovudinewith didanosine or with . . . [Full Text of this Article]
Levine, A. M., Seneviratne, L., Espina, B. M., Wohl, A. R., Tulpule, A., Nathwani, B. N., Gill, P. S.
(2000). Evolving characteristics of AIDS-related lymphoma. Blood
96: 4084-4090
[Abstract][Full Text]
Phillips, A. N., Smith, G. D., Feder, H. M., Milch, L. R., Srinivasan, V., Beidas, S. O., Corey, L., Holmes, K. K., Katzenstein, D., The AIDS Clinical Trials Group, , Study 175 Investigators,
(1997). Viral Load and Combination Therapy for Human Immunodeficiency Virus. NEJM
336: 958-961
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(1996). Patterns Emerge from ACGT 175, Delta, and CPCRA 007. AIDS Clin Care
1996: 3-3
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