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Editorial
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Volume 335:1142-1144 October 10, 1996 Number 15
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Therapy for Human Immunodeficiency Virus Infection — What Have We Learned?

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In this issue of the Journal three important articles appear, with major implications for the clinical management of infection with the human immunodeficiency virus (HIV).1,2,3 Hammer et al.1 and Katzenstein et al.2 describe the clinical and virologic results of the AIDS Clinical Trials Group Study 175 (ACTG 175), a large trial involving more than 2400 HIV-infected persons with CD4 cell counts from 200 to 500 cells per cubic millimeter. This trial clearly shows that antiretroviral therapy in such patients delays the progression of disease to AIDS and reduces mortality. Didanosine alone and the combination of zidovudine with didanosine or with . . . [Full Text of this Article]

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Viral Load and Combination Therapy for Human Immunodeficiency Virus
Phillips A. N., Smith G. D., Feder H. M., Milch L. R., Srinivasan V., Beidas S. O., Corey L., Holmes K. K., Katzenstein D., The AIDS Clinical Trials Group , Study 175 Investigators
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N Engl J Med 1997; 336:958-961, Mar 27, 1997. Correspondence

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