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Editorial
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Volume 335:1144-1145 October 10, 1996 Number 15
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Familial Hypocalcemia — Not Hypoparathyroidism

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Familial benign hypercalcemia, also known as familial hypocalciuric hypercalcemia, was first identified clinically when patients thought to have primary hyperparathyroidism whose condition did not improve after neck surgery were found to have relatives with hypercalcemia, thus suggesting a dominantly inherited condition.1 Unlike the index patient, the other affected family members were almost invariably asymptomatic.2,3 Although there were minor differences in serum and urinary biochemical values, such as lower urinary calcium excretion, in these patients as compared with patients with primary hyperparathyroidism, the two conditions have many similarities. The main danger of familial benign hypercalcemia is an unnecessary parathyroidectomy. The subsequent . . . [Full Text of this Article]

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