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Previous Volume 335:1222-1224 October 17, 1996 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Beginning in 1991, our understanding of the molecular bases of nine important neurologic diseases has burgeoned. A new class of molecular disease has been identified, defined by the abnormal, unstable expansion of DNA-triplet repeats in the mutant, causal gene for each of these disorders. In this issue of the Journal, Dürr et al.¹ report on a large series of patients with the triplet DNA expansion that causes Friedreich's ataxia. This report should be understood in the context of the molecular genetics of this group of neurologic diseases.

The first triplet disease described was the fragile X syndrome, which has been . . . [Full Text of this Article]

References

Related Letters:

Genetic Abnormalities in Friedreich's Ataxia
Dutka D. P., Nunez D. J.R., Filla A., De Michele G., Cocozza S., Madhani H. D., Dürr A., Brice A., Koenig M., Rosenberg R. N.
Extract | Full Text  
N Engl J Med 1997; 336:1021-1023, Apr 3, 1997. Correspondence

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