FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 335:1290-1302 October 24, 1996 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

The goal of therapy in patients with coronary artery disease is to alleviate symptoms of angina and reduce the risk of death or nonfatal myocardial infarction. Although coronary angioplasty immediately reduces anginal symptoms in almost all patients who undergo it, its use is associated with death or nonfatal myocardial infarction in about 5 percent of patients^{1,2,3,4,5,6,7,8} and with restenosis requiring repeated angioplasty or bypass surgery in about 30 percent.^3,4,5,6,9 Recently, several clinical trials have shown that the implantation of coronary stents^5,6 or treatment with blockers of platelet glycoprotein IIb/IIIa receptors^10,11,12 reduces the occurrence of acute complications and restenosis in patients . . . [Full Text of this Article]

Devices for Coronary Revascularization

Balloon Angioplasty

Atherectomy and Laser Angioplasty

Coronary Stenting

            Current Applications

            Subacute Thrombotic Occlusion of Coronary Stents

            Innovations in Coronary Stents

            Coronary Stenting and the Process of Restenosis

New Antithrombotic Therapies for Use during Coronary Angioplasty

Thrombolytic Therapy as Adjunctive Therapy

Comparison of Angioplasty with Other Therapies

PTCA versus Medical Therapy

PTCA versus Bypass Surgery

Relation between Severity of Stenosis and Clinical Outcome

Conclusions

Source Information

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.

Address reprint requests to Dr. Bittl at the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.

References

This article has been cited by other articles:

• Serruys, P. W., Morice, M.-C., Kappetein, A. P., Colombo, A., Holmes, D. R., Mack, M. J., Stahle, E., Feldman, T. E., van den Brand, M., Bass, E. J., Van Dyck, N., Leadley, K., Dawkins, K. D., Mohr, F. W., the SYNTAX Investigators, (2009). Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease. NEJM 360: 961-972 [Abstract] [Full Text]  
• Zernecke, A., Bernhagen, J., Weber, C. (2008). Macrophage Migration Inhibitory Factor in Cardiovascular Disease. Circulation 117: 1594-1602 [Abstract] [Full Text]  
• Walcher, D., Babiak, C., Poletek, P., Rosenkranz, S., Bach, H., Betz, S., Durst, R., Grub, M., Hombach, V., Strong, J., Marx, N. (2006). C-Peptide Induces Vascular Smooth Muscle Cell Proliferation: Involvement of Src-Kinase, Phosphatidylinositol 3-Kinase, and Extracellular Signal-Regulated Kinase 1/2. Circ. Res. 99: 1181-1187 [Abstract] [Full Text]  
• Sprung, J., Ritter, M. J., Rihal, C. S., Warner, M. E., Wilson, G. A., Williams, B. A., Stevens, S. R., Schroeder, D. R., Bourke, D. L., Warner, D. O. (2006). Outcomes of Cardiopulmonary Resuscitation and Predictors of Survival in Patients Undergoing Coronary Angiography Including Percutaneous Coronary Interventions. Anesth. Analg. 102: 217-224 [Abstract] [Full Text]  
• Marx, N., Wohrle, J., Nusser, T., Walcher, D., Rinker, A., Hombach, V., Koenig, W., Hoher, M. (2005). Pioglitazone Reduces Neointima Volume After Coronary Stent Implantation: A Randomized, Placebo-Controlled, Double-Blind Trial in Nondiabetic Patients. Circulation 112: 2792-2798 [Abstract] [Full Text]  
• Butany, J, Carmichael, K, Leong, S W, Collins, M J (2005). Coronary artery stents: identification and evaluation. J. Clin. Pathol. 58: 795-804 [Abstract] [Full Text]  
• Fujiyama, S., Amano, K., Uehira, K., Yoshida, M., Nishiwaki, Y., Nozawa, Y., Jin, D., Takai, S., Miyazaki, M., Egashira, K., Imada, T., Iwasaka, T., Matsubara, H. (2003). Bone Marrow Monocyte Lineage Cells Adhere on Injured Endothelium in a Monocyte Chemoattractant Protein-1-Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor Cells. Circ. Res. 93: 980-989 [Abstract] [Full Text]  
• Uwatoku, T., Shimokawa, H., Abe, K., Matsumoto, Y., Hattori, T., Oi, K., Matsuda, T., Kataoka, K., Takeshita, A. (2003). Application of Nanoparticle Technology for the Prevention of Restenosis After Balloon Injury in Rats. Circ. Res. 92 : e62-e69 [Abstract] [Full Text]  
• Laukkanen, M. O., Kivela, A., Rissanen, T., Rutanen, J., Karkkainen, M. K., Leppanen, O., Brasen, J. H., Yla-Herttuala, S. (2002). Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta. Circulation 106: 1999-2003 [Abstract] [Full Text]  
• Ruscazio, M., Montisci, R., Colonna, P., Caiati, C., Chen, L., Lai, G., Cadeddu, M., Pirisi, R., Iliceto, S. (2002). Detection of coronary restenosis aftercoronary angioplasty by contrast-enhanced transthoracic echocardiographic Doppler assessment of coronary flow velocity reserve. J Am Coll Cardiol 40: 896-903 [Abstract] [Full Text]  
• Kinlay, S., Grewal, J., Manuelin, D., Fang, J. C., Selwyn, A. P., Bittl, J. A., Ganz, P. (2002). Coronary Flow Velocity and Disturbed Flow Predict Adverse Clinical Outcome After Coronary Angioplasty. Arterioscler. Thromb. Vasc. Bio. 22: 1334-1340 [Abstract] [Full Text]  
• Zuckerbraun, B. S., Tzeng, E. (2002). Vascular Gene Therapy: A Reality of the 21st Century. Arch Surg 137: 854-861 [Abstract] [Full Text]  
• Christen, T., Verin, V., Bochaton-Piallat, M.-L., Popowski, Y., Ramaekers, F., Debruyne, P., Camenzind, E., van Eys, G., Gabbiani, G. (2001). Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery. Circulation 103: 882-888 [Abstract] [Full Text]  
• Roque, M., Reis, E. D., Fuster, V., Padurean, A., Fallon, J. T., Taubman, M. B., Chesebro, J. H., Badimon, J. J. (2000). Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty. J Am Coll Cardiol 36: 2303-2310 [Abstract] [Full Text]  
• Hiltunen, M. O., Laitinen, M., Turunen, M. P., Jeltsch, M., Hartikainen, J., Rissanen, T. T., Laukkanen, J., Niemi, M., Kossila, M., Hakkinen, T. P., Kivela, A., Enholm, B., Mansukoski, H., Turunen, A.-M., Alitalo, K., Yla-Herttuala, S. (2000). Intravascular Adenovirus-Mediated VEGF-C Gene Transfer Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta. Circulation 102: 2262-2268 [Abstract] [Full Text]  
• Yellon, D. M., Dana, A. (2000). The Preconditioning Phenomenon : A Tool for the Scientist or a Clinical Reality?. Circ. Res. 87: 543-550 [Abstract] [Full Text]  
• Mach, F. (2000). Toward New Therapeutic Strategies Against Neointimal Formation in Restenosis. Arterioscler. Thromb. Vasc. Bio. 20: 1699-1700 [Full Text]  
• Windecker, S., Meier, B. (2000). CORONARY DISEASE: Intervention in coronary artery disease. Heart 83: 481-481 [Full Text]  
• Hiltunen, M. O, Turunen, M. P, Laitinen, M., Yla-Herttuala, S. (2000). Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer. Vasc Med 5: 41-48 [Abstract]  
• Mishkel, G. J., Aguirre, F. V., Ligon, R. W., Rocha-Singh, K. J., Lucore, C. L., for Prairie Cardiovascular Consultants Ltd, (1999). Clopidogrel as adjunctive antiplatelet therapy during coronary stenting. J Am Coll Cardiol 34: 1884-1890 [Abstract] [Full Text]  
• O'Connor, G. T., Malenka, D. J., Quinton, H., Robb, J. F., Kellett, M. A. Jr., Shubrooks, S., Bradley, W. A., Hearne, M. J., Watkins, M. W., Wennberg, D. E., Hettleman, B., O'Rourke, D. J., McGrath, P. D., Ryan, T. Jr., VerLee, P., for the Northern New England Cardiovascular Diseas, (1999). Multivariate prediction of in-hospital mortality after percutaneous coronary interventions in 1994-1996. J Am Coll Cardiol 34: 681-691 [Abstract] [Full Text]  
• Lloyd, C. T., Calafiore, A. M., Wilde, P., Ascione, R., Paloscia, L., Monk, C. R., Angelini, G. D. (1999). Integrated left anterior small thoracotomy and angioplasty for coronary artery revascularization. Ann. Thorac. Surg. 68: 908-911 [Abstract] [Full Text]  
• Sun, L.-Q., Cairns, M. J., Gerlach, W. L., Witherington, C., Wang, L., King, A. (1999). Suppression of Smooth Muscle Cell Proliferation by a c-myc RNA-cleaving Deoxyribozyme. J. Biol. Chem. 274: 17236-17241 [Abstract] [Full Text]  
• Rill, V., Brown, D. L. (1999). Practice of Coronary Angioplasty in California in 1995 : Comparison to 1989 and Impact of Coronary Stenting. Circulation 99 : e12-e12 [Abstract] [Full Text]  
• Windecker, S., Maier-Rudolph, W., Bonzel, T., Heyndrickx, G., Lablanche, J.M., Morice, M.C., Muhlberger, V., Neuhaus, K.L., Piscione, F., van den Brand, M., Wijns, W., Meier, B., Working Group Coronary Circulation of the European, (1999). Interventional cardiology in Europe 1995. Eur Heart J 20: 484-495 [Abstract]  
• Fareh, J., Martel, R., Kermani, P., Leclerc, G. (1999). Cellular Effects of ß-Particle Delivery on Vascular Smooth Muscle Cells and Endothelial Cells : A Dose-Response Study. Circulation 99: 1477-1484 [Abstract] [Full Text]  
• Muranaka, Y., Yamasaki, Y., Nozawa, Y., Terakawa, H., Tanahashi, Y., Oda, N., Satoh, A., Asao, T., Miyake, H., Matsuura, N. (1998). TAS-301, an Inhibitor of Smooth Muscle Cell Migration and Proliferation, Inhibits Intimal Thickening after Balloon Injury to Rat Carotid Arteries. J. Pharmacol. Exp. Ther. 285: 1280-1286 [Abstract] [Full Text]  
• Kornowski, R., Mehran, R., Hong, M. K., Satler, L. F., Pichard, A. D., Kent, K. M., Mintz, G. S., Waksman, R., Laird, J. R., Lansky, A. J., Bucher, T. A., Popma, J. J., Leon, M. B. (1998). Procedural Results and Late Clinical Outcomes After Placement of Three or More Stents in Single Coronary Lesions. Circulation 97: 1355-1361 [Abstract] [Full Text]  
• Achenbach, S., Moshage, W., Bachmann, K. (1997). Detection of High-Grade Restenosis After PTCA Using Contrast-Enhanced Electron Beam CT. Circulation 96: 2785-2788 [Abstract] [Full Text]  
• Chaitman, B. R., Rosen, A. D., Williams, D. O., Bourassa, M. G., Aguirre, F. V., Pitt, B., Rautaharju, P. M., Rogers, W. J., Sharaf, B., Attubato, M., Hardison, R. M., Srivatsa, S., Kouchoukos, N. T., Stocke, K., Sopko, G., Detre, K., Frye, R. (1997). Myocardial Infarction and Cardiac Mortality in the Bypass Angioplasty Revascularization Investigation (BARI) Randomized Trial. Circulation 96: 2162-2170 [Abstract] [Full Text]