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Previous Volume 335:1389-1391 October 31, 1996 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The importance of insulin-like growth factor I (IGF-I) in regulating the effects of growth hormone on postnatal growth and development is well established, but its role during the prenatal period is not. Postnatally, the synthesis and release of IGF-I and its carriers — the IGF-binding proteins — are induced by the binding of growth hormone to its receptors in the liver. IGF-II, on the other hand, is not dependent on growth hormone. IGF-I acts by means of receptors for IGF-I and perhaps insulin, and IGF-II acts by means of a mannose-6-phosphate receptor. An understanding of how the system functions prenatally . . . [Full Text of this Article]

References

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