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Original Article
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Volume 335:1494-1497 November 14, 1996 Number 20
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Genetic Analysis of a Sarcoma Accidentally Transplanted from a Patient to a Surgeon
Hermine-Valeria Gärtner, M.D., Christian Seidl, M.D., Christine Luckenbach, Ph.D., Georg Schumm, M.D., Erhard Seifried, M.D., Horst Ritter, M.D., and Burkhard Bültmann, M.D.

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Modern concepts of cancer immunology originated from the classic observations by Jensen, Loeb, Tyzzer, and Little in the early years of the 20th century of the rejection of transplanted allogeneic tumors and the acceptance of syngeneic tumors.1 Despite this law of transplantation, there are several clinical examples of the accidental transplantation of a malignant tumor or tumor cells into a healthy recipient.2,3,4,5

We describe the accidental transplantation of a malignant sarcoma from a patient to a surgeon. Using molecular methods, we showed that the sarcomas in the unrelated patient and surgeon were genetically identical.

Case Report

A 32-year-old man underwent emergency surgery . . . [Full Text of this Article]

Methods

Histologic and Immunohistologic Analysis

Isolation of DNA

Analysis of Short Tandem-Repeat Polymorphisms

Sequence-Based Typing of HLA Genes

Results

Discussion


Source Information

From the Institutes of Pathology (H.-V.G., B.B.) and Anthropology and Human Genetics (C.L., H.R.), Eberhard-Karls-Universität, Tübingen; the Institute of Transfusion Medicine and Immunohematology, Red Cross Blood Donor Service, Frankfurt am Main (C.S., E.S.); and the Institute of Pathology, General Hospital, Heilbronn (G.S.) — all in Germany.

Address reprint requests to Dr. Gärtner at the Institute of Pathology, Eberhard-Karls-Universität, Liebermeisterstraße 8, D-72076 Tübingen, Germany.

References


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