FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 335:1538-1539 November 14, 1996 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

To the Editor: Severe poisoning with -adrenergic–receptor blocking agents, which leads to decreased production of cellular cyclic AMP and impaired release of calcium from the sarcoplasmic reticulum, causes bradycardia and hypotension that can be refractory to treatment with catecholamines, calcium, and glucagon.¹ We report on a patient with a life-threatening overdose of metoprolol, whose hemodynamic condition improved dramatically with the administration of enoximone, an inhibitor of phosphodiesterase III.

The patient was a 55-year-old woman who intentionally ingested metoprolol in a total dose of 10 g. She was found unconscious about one hour later, with a heart rate of 55 beats . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Vroom, M. B. (1998). Pharmacologic Management of Acute Heart Failure: A Review. SEMIN CARDIOTHORAC VASC ANESTH 2: 191-203 [Abstract]