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Previous Volume 335:1607-1609 November 21, 1996 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Fisher et al. (June 27 issue)¹ report on the treatment of septic shock with the tumor necrosis factor (TNF) receptor:Fc fusion protein (TNFR:Fc). The results of their study are a disappointment to those of us who hoped that modification of circulating TNF levels might improve the outcome of septic shock.

The conclusion by Fisher et al. that "treatment with the TNFR:Fc fusion protein does not reduce mortality, and higher doses appear to be associated with increased mortality" is valid given the results of their study. However, I am concerned that only 4 percent of all the patients . . . [Full Text of this Article]

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