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Editorial
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Volume 335:1678-1680 November 28, 1996 Number 22
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Beginning to Make Progress against HIV

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For nearly three years we have known that zidovudine is efficacious in preventing transmission of the human immunodeficiency virus (HIV) from mother to infant.1 A randomized, placebo-controlled trial, AIDS Clinical Trials Group Protocol 076, established a new standard of care for pregnant women with HIV type 1 infection. This issue of the Journal includes the report by Sperling et al. of an analysis of Protocol 076 after 402 mother–infant pairs were followed for 18 months.2 During that period, 15 infants in the zidovudine group (7.6 percent) and 46 infants in the placebo group (22.6 percent) were found to be infected. . . . [Full Text of this Article]

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