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Correspondence
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Volume 335:1690 November 28, 1996 Number 22
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Absence of Herpesvirus in AIDS-Associated Smooth-Muscle Tumors

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To the Editor: Last year we reported finding Epstein–Barr virus (EBV) in smooth-muscle–tumor cells in leiomyosarcoma tissues from patients with the acquired immunodeficiency syndrome (AIDS).1 This was the first evidence of EBV infection of nonlymphoid cells of mesenchymal origin. Almost simultaneously, evidence of a new herpesvirus, known as Kaposi's sarcoma–associated herpesvirus (KSHV) or human herpesvirus 8, was found in Kaposi's sarcoma tissues from patients with AIDS.2 The mesenchymal origin of both leiomyosarcoma and Kaposi's sarcoma and the recent demonstration of coinfection of cells of body-cavity–based B-cell lymphomas by both EBV and this new herpesvirus3 suggested that KSHV may also coinfect . . . [Full Text of this Article]

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