FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 335:1839-1840 December 12, 1996 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

The transplantation of allogeneic hematopoietic stem cells is being used to treat thousands of adults and children with life-threatening hematologic diseases. In the absence of a suitable HLA-identical sibling donor, possible alternatives are mismatched related or matched unrelated donors. But with cells from these donors, major and minor histocompatibility differences, which often go unrecognized by current matching tests, are a frequent cause of post-transplantation complications, graft failure, graft-versus-host disease, and delayed immune reconstitution. In the absence of a perfectly matched donor, several means of circumventing the HLA barrier are possible. Some of these depend on the special hematologic and immunologic . . . [Full Text of this Article]

References

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.