FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 335:1956-1962 December 26, 1996 Number 26 Next

Interferon- –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

The attenuated strain of Mycobacterium bovis bacille Calmette–Guérin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it occasionally leads to a benign regional adenitis.¹ In rare cases, however, vaccination causes disseminated BCG infection, which may be lethal. Impaired immunity of the host is generally thought to be the pathogenic mechanism. Disseminated BCG infection has been reported in children with inherited immune disorders. Most of these children had severe combined immunodeficiency, which is characterized by an absence of T cells, and some had chronic granulomatous disease, which is . . . [Full Text of this Article]

Case Report

Methods

Microsatellites

Sequencing of Complementary DNA

Genomic PCR

Northern Blotting

Assay of ¹²⁵I-Labeled–Interferon- Binding

Cell Staining

Results

Discussion

Source Information

From INSERM Unité 429 (E.J., F.A., S.L., P.R., A.F., J.-L.C.) and the Department of Pathology (J.-F.E.), Hôpital Necker–Enfants Malades, Paris; the Department of Pediatrics, Imperial College of Science, Technology, and Medicine, St. Mary's Hospital, London (M.N., M.L.); Genethon Laboratories, Evry, France (E.S.); and Unité d'Immunologie et Hématologie Pédiatrique, Hôpital Necker, Paris (S.B., A.F., J.-L.C.).

Address reprint requests to Dr. Casanova at INSERM U429, Pavillon Kirmisson, Hôpital Necker –Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.

References

This article has been cited by other articles:

• Zhu, J., Paul, W. E. (2008). CD4 T cells: fates, functions, and faults. Blood 112: 1557-1569 [Abstract] [Full Text]  
• Dale, D. C., Boxer, L., Liles, W. C. (2008). The phagocytes: neutrophils and monocytes. Blood 112: 935-945 [Abstract] [Full Text]  
• Hussain, R., Talat, N., Shahid, F., Dawood, G. (2007). Longitudinal Tracking of Cytokines after Acute Exposure to Tuberculosis: Association of Distinct Cytokine Patterns with Protection and Disease Development. CVI 14: 1578-1586 [Abstract] [Full Text]  
• Pennini, M. E., Liu, Y., Yang, J., Croniger, C. M., Boom, W. H., Harding, C. V. (2007). CCAAT/Enhancer-Binding Protein beta and {delta} Binding to CIITA Promoters Is Associated with the Inhibition of CIITA Expression in Response to Mycobacterium tuberculosis 19-kDa Lipoprotein. J. Immunol. 179: 6910-6918 [Abstract] [Full Text]  
• Coelho, A. L., Schaller, M. A., Benjamim, C. F., Orlofsky, A. Z., Hogaboam, C. M., Kunkel, S. L. (2007). The Chemokine CCL6 Promotes Innate Immunity via Immune Cell Activation and Recruitment. J. Immunol. 179: 5474-5482 [Abstract] [Full Text]  
• Giannoudis, P. V., van Griensven, M., Tsiridis, E., Pape, H. C. (2007). The genetic predisposition to adverse outcome after trauma. J Bone Joint Surg Br 89-B: 1273-1279 [Abstract] [Full Text]  
• Okada, S., Ishikawa, N., Shirao, K., Kawaguchi, H., Tsumura, M., Ohno, Y., Yasunaga, S., Ohtsubo, M., Takihara, Y., Kobayashi, M. (2007). The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-{gamma} receptor 1 and has a dominant-negative effect on interferon-{gamma} signal transduction. J. Med. Genet. 44: 485-491 [Abstract] [Full Text]  
• Plitas, G., Chaudhry, U. I., Kingham, T. P., Raab, J. R., DeMatteo, R. P. (2007). NK Dendritic Cells Are Innate Immune Responders to Listeria monocytogenes Infection. J. Immunol. 178: 4411-4416 [Abstract] [Full Text]  
• Loeuillet, C., Martinon, F., Perez, C., Munoz, M., Thome, M., Meylan, P. R. (2006). Mycobacterium tuberculosis Subverts Innate Immunity to Evade Specific Effectors. J. Immunol. 177: 6245-6255 [Abstract] [Full Text]  
• Filipe-Santos, O., Bustamante, J., Haverkamp, M. H., Vinolo, E., Ku, C.-L., Puel, A., Frucht, D. M., Christel, K., von Bernuth, H., Jouanguy, E., Feinberg, J., Durandy, A., Senechal, B., Chapgier, A., Vogt, G., de Beaucoudrey, L., Fieschi, C., Picard, C., Garfa, M., Chemli, J., Bejaoui, M., Tsolia, M. N., Kutukculer, N., Plebani, A., Notarangelo, L., Bodemer, C., Geissmann, F., Israel, A., Veron, M., Knackstedt, M., Barbouche, R., Abel, L., Magdorf, K., Gendrel, D., Agou, F., Holland, S. M., Casanova, J.-L. (2006). X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. J. Exp. Med. 203: 1745-1759 [Abstract] [Full Text]  
• Field, S. K., Cowie, R. L. (2006). Lung Disease Due to the More Common Nontuberculous Mycobacteria. Chest 129: 1653-1672 [Abstract] [Full Text]  
• Demissie, A., Wassie, L., Abebe, M., Aseffa, A., Rook, G., Zumla, A., Andersen, P., Doherty, T. M., the VACSEL Study Group, (2006). The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon.. Infect. Immun. 74: 2817-2822 [Abstract] [Full Text]  
• Koch, O., Kwiatkowski, D. P., Udalova, I. A. (2006). Context-specific functional effects of IFNGR1 promoter polymorphism. Hum Mol Genet 15: 1475-1481 [Abstract] [Full Text]  
• Pennini, M. E., Pai, R. K., Schultz, D. C., Boom, W. H., Harding, C. V. (2006). Mycobacterium tuberculosis 19-kDa Lipoprotein Inhibits IFN-{gamma}-Induced Chromatin Remodeling of MHC2TA by TLR2 and MAPK Signaling. J. Immunol. 176: 4323-4330 [Abstract] [Full Text]  
• Khan, S., Kolls, J. K. (2006). Malnutrition in the Critically III: Don't Hold the Leptin. Am. J. Respir. Crit. Care Med. 173: 140-141 [Full Text]  
• Sghiri, R., Feinberg, J., Thabet, F., Dellagi, K., Boukadida, J., Ben Abdelaziz, A., Casanova, J. L., Barbouche, M. R. (2005). Gamma Interferon Is Dispensable for Neopterin Production In Vivo. CVI 12: 1437-1441 [Abstract] [Full Text]  
• Mukherjee, S., Kashino, S. S., Zhang, Y., Daifalla, N., Rodrigues, V. Jr, Reed, S. G., Campos-Neto, A. (2005). Cloning of the Gene Encoding a Protective Mycobacterium tuberculosis Secreted Protein Detected In Vivo during the Initial Phases of the Infectious Process. J. Immunol. 175: 5298-5305 [Abstract] [Full Text]  
• Doherty, T. M., Andersen, P. (2005). Vaccines for Tuberculosis: Novel Concepts and Recent Progress. Clin. Microbiol. Rev. 18: 687-702 [Abstract] [Full Text]  
• Tzioupis, C. C, Katsoulis, S., Manidakis, N., Giannoudis, P. V (2005). The immuno-inflammatory response to trauma. Trauma 7: 171-183 [Abstract]  
• Shin, S. J., Chang, C.-F., Chang, C.-D., McDonough, S. P., Thompson, B., Yoo, H. S., Chang, Y.-F. (2005). In Vitro Cellular Immune Responses to Recombinant Antigens of Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 73: 5074-5085 [Abstract] [Full Text]  
• Casanova, J.-L., Abel, L. (2005). Inborn errors of immunity to infection: the rule rather than the exception. J. Exp. Med. 202: 197-201 [Abstract] [Full Text]  
• Bonanni, D., Rindi, L., Lari, N., Garzelli, C. (2005). Immunogenicity of mycobacterial PPE44 (Rv2770c) in Mycobacterium bovis BCG-infected mice. J Med Microbiol 54: 443-448 [Abstract] [Full Text]  
• Roberts, C. S., Pape, H.-C., Jones, A. L., Malkani, A. L., Rodriguez, J. L., Giannoudis, P. V. (2005). Damage Control Orthopaedics. Evolving Concepts in the Treatment of Patients Who Have Sustained Orthopaedic Trauma. JBJS 87: 434-449 [Full Text]  
• Kampmann, B., Tena, G. N., Mzazi, S., Eley, B., Young, D. B., Levin, M. (2004). Novel Human In Vitro System for Evaluating Antimycobacterial Vaccines. Infect. Immun. 72: 6401-6407 [Abstract] [Full Text]  
• Fieschi, C., Bosticardo, M., de Beaucoudrey, L., Boisson-Dupuis, S., Feinberg, J., Santos, O. F., Bustamante, J., Levy, J., Candotti, F., Casanova, J.-L. (2004). A novel form of complete IL-12/IL-23 receptor {beta}1 deficiency with cell surface-expressed nonfunctional receptors. Blood 104: 2095-2101 [Abstract] [Full Text]  
• Bream, J. H., Hodge, D. L., Gonsky, R., Spolski, R., Leonard, W. J., Krebs, S., Targan, S., Morinobu, A., O'Shea, J. J., Young, H. A. (2004). A Distal Region in the Interferon-{gamma} Gene Is a Site of Epigenetic Remodeling and Transcriptional Regulation by Interleukin-2. J. Biol. Chem. 279: 41249-41257 [Abstract] [Full Text]  
• Rosenzweig, S. D., Dorman, S. E., Uzel, G., Shaw, S., Scurlock, A., Brown, M. R., Buckley, R. H., Holland, S. M. (2004). A Novel Mutation in IFN-{gamma} Receptor 2 with Dominant Negative Activity: Biological Consequences of Homozygous and Heterozygous States. J. Immunol. 173: 4000-4008 [Abstract] [Full Text]  
• Hallstrand, T.S., Ochs, H.D., Zhu, Q., Liles, W.C. (2004). Inhaled IFN-{gamma} for persistent nontuberculous mycobacterial pulmonary disease due to functional IFN-{gamma} deficiency. Eur Respir J 24: 367-370 [Abstract] [Full Text]  
• Gehring, A. J., Dobos, K. M., Belisle, J. T., Harding, C. V., Boom, W. H. (2004). Mycobacterium tuberculosis LprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human Macrophage Class II MHC Antigen Processing. J. Immunol. 173: 2660-2668 [Abstract] [Full Text]  
• Field, S. K., Fisher, D., Cowie, R. L. (2004). Mycobacterium avium complex Pulmonary Disease in Patients Without HIV Infection. Chest 126: 566-581 [Abstract] [Full Text]  
• Skeiky, Y. A. W., Alderson, M. R., Ovendale, P. J., Guderian, J. A., Brandt, L., Dillon, D. C., Campos-Neto, A., Lobet, Y., Dalemans, W., Orme, I. M., Reed, S. G. (2004). Differential Immune Responses and Protective Efficacy Induced by Components of a Tuberculosis Polyprotein Vaccine, Mtb72F, Delivered as Naked DNA or Recombinant Protein. J. Immunol. 172: 7618-7628 [Abstract] [Full Text]  
• Demissie, A., Abebe, M., Aseffa, A., Rook, G., Fletcher, H., Zumla, A., Weldingh, K., Brock, I., Andersen, P., Doherty, T. M. (2004). Healthy Individuals That Control a Latent Infection with Mycobacterium tuberculosis Express High Levels of Th1 Cytokines and the IL-4 Antagonist IL-4{delta}2. J. Immunol. 172: 6938-6943 [Abstract] [Full Text]  
• Casanova, J.-L., Abel, L. (2004). Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?. J. Exp. Med. 199: 1295-1299 [Abstract] [Full Text]  
• Lim, M. S., Elenitoba-Johnson, K. S.J. (2004). The Molecular Pathology of Primary Immunodeficiencies. J. Mol. Diagn. 6: 59-83 [Full Text]  
• Awomoyi, A A, Nejentsev, S, Richardson, A, Hull, J, Koch, O, Podinovskaia, M, Todd, J A, McAdam, K P W J, Blackwell, J M, Kwiatkowski, D, Newport, M J (2004). No association between interferon-{gamma} receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample. Thorax 59: 291-294 [Abstract] [Full Text]  
• Toyoda, H., Ido, M., Hayashi, T., Gabazza, E. C., Suzuki, K., Bu, J., Tanaka, S., Nakano, T., Kamiya, H., Chipeta, J., Kisenge, R. R., Kang, J., Hori, H., Komada, Y. (2004). Impairment of IL-12-Dependent STAT4 Nuclear Translocation in a Patient with Recurrent Mycobacterium avium Infection. J. Immunol. 172: 3905-3912 [Abstract] [Full Text]  
• Holten-Andersen, L., Doherty, T. M., Korsholm, K. S., Andersen, P. (2004). Combination of the Cationic Surfactant Dimethyl Dioctadecyl Ammonium Bromide and Synthetic Mycobacterial Cord Factor as an Efficient Adjuvant for Tuberculosis Subunit Vaccines. Infect. Immun. 72: 1608-1617 [Abstract] [Full Text]  
• Ogus, A.C., Yoldas, B., Ozdemir, T., Uguz, A., Olcen, S., Keser, I., Coskun, M., Cilli, A., Yegin, O. (2004). The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 23: 219-223 [Abstract] [Full Text]  
• Schroder, K., Hertzog, P. J., Ravasi, T., Hume, D. A. (2004). Interferon-{gamma}: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75: 163-189 [Abstract] [Full Text]  
• Fuller, C. L., Flynn, J. L., Reinhart, T. A. (2003). In Situ Study of Abundant Expression of Proinflammatory Chemokines and Cytokines in Pulmonary Granulomas That Develop in Cynomolgus Macaques Experimentally Infected with Mycobacterium tuberculosis. Infect. Immun. 71: 7023-7034 [Abstract] [Full Text]  
• Andrews, T., Sullivan, K. E. (2003). Infections in Patients with Inherited Defects in Phagocytic Function. Clin. Microbiol. Rev. 16: 597-621 [Abstract] [Full Text]  
• Shaw, M. H., Boyartchuk, V., Wong, S., Karaghiosoff, M., Ragimbeau, J., Pellegrini, S., Muller, M., Dietrich, W. F., Yap, G. S. (2003). A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity. Proc. Natl. Acad. Sci. USA 100: 11594-11599 [Abstract] [Full Text]  
• Dieli, F., Taniguchi, M., Kronenberg, M., Sidobre, S., Ivanyi, J., Fattorini, L., Iona, E., Orefici, G., De Leo, G., Russo, D., Caccamo, N., Sireci, G., Di Sano, C., Salerno, A. (2003). An Anti-Inflammatory Role for V{alpha}14 NK T cells in Mycobacterium bovis Bacillus Calmette-Guerin-Infected Mice. J. Immunol. 171: 1961-1968 [Abstract] [Full Text]  
• Weyand, C. M., Goronzy, J. J. (2003). Medium- and Large-Vessel Vasculitis. NEJM 349: 160-169 [Full Text]  
• Koguchi, Y., Kawakami, K., Uezu, K., Fukushima, K., Kon, S., Maeda, M., Nakamoto, A., Owan, I., Kuba, M., Kudeken, N., Azuma, M., Yara, S., Shinzato, T., Higa, F., Tateyama, M., Kadota, J.-I., Mukae, H., Kohno, S., Uede, T., Saito, A. (2003). High Plasma Osteopontin Level and Its Relationship with Interleukin-12-mediated Type 1 T Helper Cell Response in Tuberculosis. Am. J. Respir. Crit. Care Med. 167: 1355-1359 [Abstract] [Full Text]  
• Condos, R., Raju, B., Canova, A., Zhao, B.-Y., Weiden, M., Rom, W. N., Pine, R. (2003). Recombinant Gamma Interferon Stimulates Signal Transduction and Gene Expression in Alveolar Macrophages In Vitro and in Tuberculosis Patients. Infect. Immun. 71: 2058-2064 [Abstract] [Full Text]  
• Huard, R. C., de Oliveira Lazzarini, L. C., Butler, W. R., van Soolingen, D., Ho, J. L. (2003). PCR-Based Method To Differentiate the Subspecies of the Mycobacterium tuberculosis Complex on the Basis of Genomic Deletions. J. Clin. Microbiol. 41: 1637-1650 [Abstract] [Full Text]  
• Bellamy, R. (2003). Interferon-{gamma} and Host Susceptibility to Tuberculosis. Am. J. Respir. Crit. Care Med. 167: 946-947 [Full Text]  
• Lopez-Maderuelo, D., Arnalich, F., Serantes, R., Gonzalez, A., Codoceo, R., Madero, R., Vazquez, J. J., Montiel, C. (2003). Interferon-{gamma} and Interleukin-10 Gene Polymorphisms in Pulmonary Tuberculosis. Am. J. Respir. Crit. Care Med. 167: 970-975 [Abstract] [Full Text]  
• Fieschi, C., Dupuis, S., Catherinot, E., Feinberg, J., Bustamante, J., Breiman, A., Altare, F., Baretto, R., Le Deist, F., Kayal, S., Koch, H., Richter, D., Brezina, M., Aksu, G., Wood, P., Al-Jumaah, S., Raspall, M., da Silva Duarte, A. J., Tuerlinckx, D., Virelizier, J.-L., Fischer, A., Enright, A., Bernhoft, J., Cleary, A. M., Vermylen, C., Rodriguez-Gallego, C., Davies, G., Blutters-Sawatzki, R., Siegrist, C.-A., Ehlayel, M. S., Novelli, V., Haas, W. H., Levy, J., Freihorst, J., Al-Hajjar, S., Nadal, D., de Moraes Vasconcelos, D., Jeppsson, O., Kutukculer, N., Frecerova, K., Caragol, I., Lammas, D., Kumararatne, D. S., Abel, L., Casanova, J.-L. (2003). Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor {beta}1 Deficiency: Medical and Immunological Implications. J. Exp. Med. 197: 527-535 [Abstract] [Full Text]  
• Majorov, K. B., Lyadova, I. V., Kondratieva, T. K., Eruslanov, E. B., Rubakova, E. I., Orlova, M. O., Mischenko, V. V., Apt, A. S. (2003). Different Innate Ability of I/St and A/Sn Mice To Combat Virulent Mycobacterium tuberculosis: Phenotypes Expressed in Lung and Extrapulmonary Macrophages. Infect. Immun. 71: 697-707 [Abstract] [Full Text]  
• Karplus, T. M., Jeronimo, S. M. B., Chang, H., Helms, B. K., Burns, T. L., Murray, J. C., Mitchell, A. A., Pugh, E. W., Braz, R. F. S., Bezerra, F. L., Wilson, M. E. (2002). Association between the Tumor Necrosis Factor Locus and the Clinical Outcome of Leishmania chagasi Infection. Infect. Immun. 70: 6919-6925 [Abstract] [Full Text]  
• Reuter, U., Roesler, J., Thiede, C., Schulz, A., Classen, C. F., Oelschlagel, U., Debatin, K.-M., Friedrich, W. (2002). Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation. Blood 100: 4234-4235 [Abstract] [Full Text]  
• Qin, Z., Kim, H.-J., Hemme, J., Blankenstein, T. (2002). Inhibition of Methylcholanthrene-induced Carcinogenesis by an Interferon {gamma} Receptor-dependent Foreign Body Reaction. J. Exp. Med. 195: 1479-1490 [Abstract] [Full Text]  
• Hickman, S. P., Chan, J., Salgame, P. (2002). Mycobacterium tuberculosis Induces Differential Cytokine Production from Dendritic Cells and Macrophages with Divergent Effects on Naive T Cell Polarization. J. Immunol. 168: 4636-4642 [Abstract] [Full Text]  
• van Crevel, R., Ottenhoff, T. H. M., van der Meer, J. W. M. (2002). Innate Immunity to Mycobacterium tuberculosis. Clin. Microbiol. Rev. 15: 294-309 [Abstract] [Full Text]  
• Olleros, M. L., Guler, R., Corazza, N., Vesin, D., Eugster, H.-P., Marchal, G., Chavarot, P., Mueller, C., Garcia, I. (2002). Transmembrane TNF Induces an Efficient Cell-Mediated Immunity and Resistance to Mycobacterium bovis Bacillus Calmette-Guerin Infection in the Absence of Secreted TNF and Lymphotoxin-{alpha}. J. Immunol. 168: 3394-3401 [Abstract] [Full Text]  
• Lang, R., Rutschman, R. L., Greaves, D. R., Murray, P. J. (2002). Autocrine Deactivation of Macrophages in Transgenic Mice Constitutively Overexpressing IL-10 Under Control of the Human CD68 Promoter. J. Immunol. 168: 3402-3411 [Abstract] [Full Text]  
• Engele, M., Castiglione, K., Schwerdtner, N., Wagner, M., Bolcskei, P., Rollinghoff, M., Stenger, S. (2002). Induction of TNF in Human Alveolar Macrophages As a Potential Evasion Mechanism of Virulent Mycobacterium tuberculosis. J. Immunol. 168: 1328-1337 [Abstract] [Full Text]  
• Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., Glimcher, L. H. (2002). Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-gamma Production in CD4 and CD8 T Cells. Science 295: 338-342 [Abstract] [Full Text]  
• Panigada, M., Sturniolo, T., Besozzi, G., Boccieri, M. G., Sinigaglia, F., Grassi, G. G., Grassi, F. (2002). Identification of a Promiscuous T-Cell Epitope in Mycobacterium tuberculosis Mce Proteins. Infect. Immun. 70: 79-85 [Abstract] [Full Text]  
• Fritz, C., Maass, S., Kreft, A., Bange, F.-C. (2002). Dependence of Mycobacterium bovis BCG on Anaerobic Nitrate Reductase for Persistence Is Tissue Specific. Infect. Immun. 70: 286-291 [Abstract] [Full Text]  
• Fairbairn, I. P., Stober, C. B., Kumararatne, D. S., Lammas, D. A. (2001). ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion. J. Immunol. 167: 3300-3307 [Abstract] [Full Text]  
• Zeerleder, S., Hack, C. E., Caliezi, C., Hebeisen, R., Wuillemin, W. A. (2001). Bacillus Calmette-Guerin sepsis: shift of an intended local toward a detrimental systemic cytotoxic immune response. Blood 98: 890-891 [Full Text]  
• Dupuis, S., Dargemont, C., Fieschi, C., Thomassin, N., Rosenzweig, S., Harris, J., Holland, S. M., Schreiber, R. D., Casanova, J.-L. (2001). Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation. Science 293: 300-303 [Abstract] [Full Text]  
• Serbina, N. V., Flynn, J. L. (2001). CD8+ T Cells Participate in the Memory Immune Response to Mycobacterium tuberculosis. Infect. Immun. 69: 4320-4328 [Abstract] [Full Text]  
• Giacomini, E., Iona, E., Ferroni, L., Miettinen, M., Fattorini, L., Orefici, G., Julkunen, I., Coccia, E. M. (2001). Infection of Human Macrophages and Dendritic Cells with Mycobacterium tuberculosis Induces a Differential Cytokine Gene Expression That Modulates T Cell Response. J. Immunol. 166: 7033-7041 [Abstract] [Full Text]  
• Boechat, N., Bouchonnet, F., Bonay, M., Grodet, A., Pelicic, V., Gicquel, B., Hance, A. J. (2001). Culture at High Density Improves the Ability of Human Macrophages to Control Mycobacterial Growth. J. Immunol. 166: 6203-6211 [Abstract] [Full Text]  
• Sakai, T., Matsuoka, M., Aoki, M., Nosaka, K., Mitsuya, H. (2001). Missense mutation of the interleukin-12 receptor {beta}1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection. Blood 97: 2688-2694 [Abstract] [Full Text]  
• Marquet, S., Schurr, E. (2001). Genetics of Susceptibility to Infectious Diseases: Tuberculosis and Leprosy as Examples. Drug Metab. Dispos. 29: 479-483 [Full Text]  
• Villella, A., Picard, C., Jouanguy, E., Dupuis, S., Popko, S., Abughali, N., Meyerson, H., Casanova, J.-L., Hostoffer, R. W. (2001). Recurrent Mycobacterium avium Osteomyelitis Associated With a Novel Dominant Interferon Gamma Receptor Mutation. Pediatrics 107: e47-e47 [Abstract] [Full Text]  
• Fieschi, C., Dupuis, S., Picard, C., Smith, C. I. E., Holland, S. M., Casanova, J.-L. (2001). High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor Deficiency. Pediatrics 107: e48-e48 [Abstract] [Full Text]  
• Rook, G.A.W., Seah, G., Ustianowski, A. (2001). M. tuberculosis: immunology and vaccination. Eur Respir J 17: 537-557 [Abstract] [Full Text]  
• Wigginton, J. E., Kirschner, D. (2001). A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis. J. Immunol. 166: 1951-1967 [Abstract] [Full Text]  
• Allende, L. M., Lopez-Goyanes, A., Paz-Artal, E., Corell, A., Garcia-Perez, M. A., Varela, P., Scarpellini, A., Negreira, S., Palenque, E., Arnaiz-Villena, A. (2001). A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency. CVI 8: 133-137 [Abstract] [Full Text]  
• Halloran, P. F., Afrouzian, M., Ramassar, V., Urmson, J., Zhu, L.-F., Helms, L. M. H., Solez, K., Kneteman, N. M. (2001). Interferon-{{gamma}} Acts Directly on Rejecting Renal Allografts to Prevent Graft Necrosis. Am. J. Pathol. 158: 215-226 [Abstract] [Full Text]  
• Skeiky, Y. A. W., Ovendale, P. J., Jen, S., Alderson, M. R., Dillon, D. C., Smith, S., Wilson, C. B., Orme, I. M., Reed, S. G., Campos-Neto, A. (2000). T Cell Expression Cloning of a Mycobacterium tuberculosis Gene Encoding a Protective Antigen Associated with the Early Control of Infection. J. Immunol. 165: 7140-7149 [Abstract] [Full Text]  
• Lekstrom-Himes, J. A., Gallin, J. I. (2000). Immunodeficiency Diseases Caused by Defects in Phagocytes. NEJM 343: 1703-1714 [Full Text]  
• Thoma-Uszynski, S., Stenger, S., Modlin, R. L. (2000). CTL-Mediated Killing of Intracellular Mycobacterium tuberculosis Is Independent of Target Cell Nuclear Apoptosis. J. Immunol. 165: 5773-5779 [Abstract] [Full Text]  
• Lyadova, I. V., Eruslanov, E. B., Khaidukov, S. V., Yeremeev, V. V., Majorov, K. B., Pichugin, A. V., Nikonenko, B. V., Kondratieva, T. K., Apt, A. S. (2000). Comparative Analysis of T Lymphocytes Recovered from the Lungs of Mice Genetically Susceptible, Resistant, and Hyperresistant to Mycobacterium tuberculosis-Triggered Disease. J. Immunol. 165: 5921-5931 [Abstract] [Full Text]  
• Olakanmi, O., Britigan, B. E., Schlesinger, L. S. (2000). Gallium Disrupts Iron Metabolism of Mycobacteria Residing within Human Macrophages. Infect. Immun. 68: 5619-5627 [Abstract] [Full Text]  
• Dovhey, S. E., Ghosh, N. S., Wright, K. L. (2000). Loss of Interferon-{{gamma}} Inducibility of TAP1 and LMP2 in a Renal Cell Carcinoma Cell Line. Cancer Res. 60: 5789-5796 [Abstract] [Full Text]  
• Schwander, S. K., Torres, M., Carranza C, C., Escobedo, D., Tary-Lehmann, M., Anderson, P., Toossi, Z., Ellner, J. J., Rich, E. A., Sada, E. (2000). Pulmonary Mononuclear Cell Responses to Antigens of Mycobacterium tuberculosis in Healthy Household Contacts of Patients with Active Tuberculosis and Healthy Controls from the Community. J. Immunol. 165: 1479-1485 [Abstract] [Full Text]  
• TAKAHASHI, M., ISHIZAKA, A., NAKAMURA, H., KOBAYASHI, K., NAKAMURA, M., NAMIKI, M., SEKITA, T., OKAJIMA, S. (2000). Specific HLA in Pulmonary MAC Infection in a Japanese Population. Am. J. Respir. Crit. Care Med. 162: 316-318 [Abstract] [Full Text]  
• Nau, G. J., Chupp, G. L., Emile, J.-F., Jouanguy, E., Berman, J. S., Casanova, J.-L., Young, R. A. (2000). Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection. Am. J. Pathol. 157: 37-42 [Abstract] [Full Text]  
• Ehlers, S., Richter, E. (2000). Gamma Interferon Is Essential for Clearing Mycobacterium genavense Infection. Infect. Immun. 68: 3720-3723 [Abstract] [Full Text]  
• Alderson, M. R., Bement, T., Day, C. H., Zhu, L., Molesh, D., Skeiky, Y. A. W., Coler, R., Lewinsohn, D. M., Reed, S. G., Dillon, D. C. (2000). Expression Cloning of an Immunodominant Family of Mycobacterium tuberculosis Antigens Using Human CD4+ T Cells. J. Exp. Med. 191: 551-560 [Abstract] [Full Text]  
• TAKEI, Y., SIMS, T. N., URMSON, J., HALLORAN, P. F. (2000). Central Role for Interferon-{gamma} Receptor in the Regulation of Renal MHC Expression. J. Am. Soc. Nephrol. 11: 250-261 [Abstract] [Full Text]  
• Rigamonti, L., Ariotti, S., Losana, G., Gradini, R., Russo, M. A., Jouanguy, E., Casanova, J.-L., Forni, G., Novelli, F. (2000). Surface Expression of the IFN-{gamma}R2 Chain Is Regulated by Intracellular Trafficking in Human T Lymphocytes. J. Immunol. 164: 201-207 [Abstract] [Full Text]  
• Ahuja, S. S., Reddick, R. L., Sato, N., Montalbo, E., Kostecki, V., Zhao, W., Dolan, M. J., Melby, P. C., Ahuja, S. K. (1999). Dendritic Cell (DC)-Based Anti-Infective Strategies: DCs Engineered to Secrete IL-12 Are a Potent Vaccine in a Murine Model of an Intracellular Infection. J. Immunol. 163: 3890-3897 [Abstract] [Full Text]  
• Serbina, N. V., Flynn, J. L. (1999). Early Emergence of CD8+ T Cells Primed for Production of Type 1 Cytokines in the Lungs of Mycobacterium tuberculosis-Infected Mice. Infect. Immun. 67: 3980-3988 [Abstract] [Full Text]  
• Hoft, D. F., Tennant, J. M. (1999). Persistence and Boosting of Bacille Calmette-Guerin-Induced Delayed-Type Hypersensitivity. ANN INTERN MED 131: 32-36 [Abstract] [Full Text]  
• Florido, M., Goncalves, A. S., Silva, R. A., Ehlers, S., Cooper, A. M., Appelberg, R. (1999). Resistance of Virulent Mycobacterium avium to Gamma Interferon-Mediated Antimicrobial Activity Suggests Additional Signals for Induction of Mycobacteriostasis. Infect. Immun. 67: 3610-3618 [Abstract] [Full Text]  
• Tang, Y.-W., Mitchell, P. S., Espy, M. J., Smith, T. F., Persing, D. H. (1999). Molecular Diagnosis of Herpes Simplex Virus Infections in the Central Nervous System. J. Clin. Microbiol. 37: 2127-2136 [Full Text]  
• Wilkinson, R. J., Patel, P., Llewelyn, M., Hirsch, C. S., Pasvol, G., Snounou, G., Davidson, R. N., Toossi, Z. (1999). Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1beta on Tuberculosis. J. Exp. Med. 189: 1863-1874 [Abstract] [Full Text]  
• Dillon, D. C., Alderson, M. R., Day, C. H., Lewinsohn, D. M., Coler, R., Bement, T., Campos-Neto, A., Skeiky, Y. A. W., Orme, I. M., Roberts, A., Steen, S., Dalemans, W., Badaro, R., Reed, S. G. (1999). Molecular Characterization and Human T-Cell Responses to a Member of a Novel Mycobacterium tuberculosis mtb39 Gene Family. Infect. Immun. 67: 2941-2950 [Abstract] [Full Text]  
• Murray, P. J., Young, R. A. (1999). Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice. Infect. Immun. 67: 3087-3095 [Abstract] [Full Text]  
• BONAY, M., BOUCHONNET, F., PELICIC, V., LAGIER, B., GRANDSAIGNE, M., LECOSSIER, D., GRODET, A., VOKURKA, M., GICQUEL, B., HANCE, A. J. (1999). Effect of Stimulation of Human Macrophages on Intracellular Survival of Mycobacterium bovis Bacillus Calmette-Guerin . Evaluation with a Mycobacterial Reporter Strain. Am. J. Respir. Crit. Care Med. 159: 1629-1637 [Abstract] [Full Text]  
• Caruso, A. M., Serbina, N., Klein, E., Triebold, K., Bloom, B. R., Flynn, J. L. (1999). Mice Deficient in CD4 T Cells Have Only Transiently Diminished Levels of IFN-{gamma}, Yet Succumb to Tuberculosis. J. Immunol. 162: 5407-5416 [Abstract] [Full Text]