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Correction to Geldmacher and Whitehouse, N Engl J Med 335(5):330-336 August 1, 1996.

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Volume 335:1996-1998 December 26, 1996 Number 26
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Evaluation of Suspected Dementia

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To the Editor: In their review of the evaluation of dementia (Aug. 1 issue),1 Geldmacher and Whitehouse expressed their "opinion . . . that apolipoprotein E testing will not be ready for clinical use as either a predictive or a diagnostic test until better population-based estimates of risk and appropriate genetic counseling are available." There is virtual unanimity regarding the lack of support for apolipoprotein E genotyping in the prediction of asymptomatic persons — whether or not they have relatives with Alzheimer's disease.2 No apolipoprotein E genotype predicts accurately whether or when Alzheimer's disease will develop. However, the rationale for . . . [Full Text of this Article]

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