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Correspondence
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Volume 335:2000-2001 December 26, 1996 Number 26
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Megaloblastosis

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 by Moll, S.
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 by Geldmacher, D. S.
To the Editor: The Image in Clinical Medicine of the peripheral-blood smear from a patient with vitamin B12 deficiency (Aug. 1 issue)1 beautifully captures many of the features of megaloblastic anemia. The author mentions that the patient's mean corpuscular volume of 103 µm3 was "very low for pure vitamin B12 deficiency of this severity and might have suggested an additional hematologic problem," but no additional abnormality was found. In fact, many patients with severe megaloblastic anemia have mean corpuscular volumes that are very elevated at first but later decline to the levels seen in this patient, while the red-cell–distribution width . . . [Full Text of this Article]

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