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Book Review
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Volume 335:2002-2003 December 26, 1996 Number 26
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The Case of the Frozen Addicts: How the solution of an extraordinary medical mystery spawned a revolution in the understanding and treatment of Parkinson's disease

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By J. William Langston and Jon Palfreman. 309 pp. New York, Pantheon, 1996. $25. ISBN 0-679-42465-2.

This book dramatically recounts the discovery of the cause of a local outbreak of sudden, severe parkinsonism in a group of young adults in northern California and how this discovery led to greater insight into Parkinson's disease. Langston is the Bay Area neurologist who reported the event and led a team of investigators to pinpoint the toxicant responsible for the acute loss of dopamine-containing neurons in the substantia nigra, causing the parkinsonism in these patients. The story unfolds and builds suspense as Langston and his colleagues determine that the toxicant is 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP was the unwanted product resulting from . . . [Full Text of this Article]



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