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Previous Volume 335:2002-2003 December 26, 1996 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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By J. William Langston and Jon Palfreman. 309 pp. New York, Pantheon, 1996. $25. ISBN 0-679-42465-2.

This book dramatically recounts the discovery of the cause of a local outbreak of sudden, severe parkinsonism in a group of young adults in northern California and how this discovery led to greater insight into Parkinson's disease. Langston is the Bay Area neurologist who reported the event and led a team of investigators to pinpoint the toxicant responsible for the acute loss of dopamine-containing neurons in the substantia nigra, causing the parkinsonism in these patients. The story unfolds and builds suspense as Langston and his colleagues determine that the toxicant is 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP was the unwanted product resulting from . . . [Full Text of this Article]

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