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Previous Volume 335:337-339 August 1, 1996 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although diseases of blood cells constitute a relatively small proportion of clinical disorders, many valuable studies of gene transfer have relied on hematopoietic stem cells or their progeny. What features of these cells explain their appeal in gene therapy? Perhaps most important is their hierarchical pattern of development (Figure 1). Fewer than 1 in 100,000 bone marrow cells are pluripotent, self-renewing hematopoietic stem cells, but these rare cells yield progeny that multiply by many hundredfold and, in the process, follow a particular blood-cell lineage (monocytic, lymphocytic, granulocytic, megakaryocytic, or erythrocytic). These committed progenitors then multiply by a hundredfold . . . [Full Text of this Article]

Source Information

From the Division of Bone Marrow Transplantation and the Cell and Gene Therapy Program, St. Jude Children's Research Hospital, Memphis, Tenn.

Address reprint requests to Dr. Brenner at the Cell and Gene Therapy Program, St. Jude Children's Research Hospital, 322 N. Lauderdale, Memphis, TN 38105-2794.

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