The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Editorial
PreviousPrevious
Volume 335:346-348 August 1, 1996 Number 5
NextNext

Tumor Necrosis Factor and the Jarisch–Herxheimer Reaction

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited

More Information
In certain infectious diseases, the first dose of an effective antimicrobial drug can trigger an inflammatory host response. Within an hour or two after receiving the drug, the patient abruptly experiences chills, followed by fever and sweating and worsening of preexisting symptoms and lesions. Hyperventilation and tachycardia are accompanied by hypertension, and then by a drop in blood pressure due to vasodilation and declining peripheral resistance. Usually, the reaction resolves over a period of 6 to 12 hours.

The identification of this distressing and sometimes fatal phenomenon is usually credited to Jarisch and Herxheimer, each of whom described components of . . . [Full Text of this Article]

References



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.