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Previous Volume 335:523-524 August 15, 1996 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Casadevall et al. (March 7 issue)¹ described the development of autoantibodies against erythropoietin in a patient with pure red-cell aplasia. The authors report the presence of IgG antibodies against endogenous erythropoietin, but there are few reports on antibodies against recombinant human erythropoietin (rHuEPO).^2,3,4

Recently, we saw a 38-year-old man treated by hemodialysis who was resistant to rHuEPO and who had anti-rHuEPO antibodies in his serum. An initial adequate response to rHuEPO (20 U per kilogram of body weight subcutaneously three times a week) was followed eight months later by a lack of response, despite the administration of . . . [Full Text of this Article]

References

This article has been cited by other articles:

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• Casadevall, N., Eckardt, K.-U., Rossert, J. (2005). Epoetin-Induced Autoimmune Pure Red Cell Aplasia. J. Am. Soc. Nephrol. 16: S67-S69 [Abstract] [Full Text]  
• Thorpe, R., Swanson, S. J (2005). Current Methods for Detecting Antibodies against Erythropoietin and Other Recombinant Proteins. CVI 12: 28-39 [Full Text]  
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• Schonholzer, C., Keusch, G., Nigg, L., Robert, D., Wauters, J.-P. (2004). High prevalence in Switzerland of pure red-cell aplasia due to anti-erythropoietin antibodies in chronic dialysis patients: report of five cases. Nephrol Dial Transplant 19: 2121-2125 [Abstract] [Full Text]  
• Summers, S. A., Matijevic, A., Almond, M. K. (2004). Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia. Nephrol Dial Transplant 19: 2137-2139 [Full Text]  
• Vartia, A., Asola, M. R., Tertti, R., Kunelius, P., Metsarinne, K. P. (2004). Two haemodialysis patients with epoetin alfa-induced pure red-cell aplasia recovered despite treatment with another epoetin preparation. Nephrol Dial Transplant 19: 1313-1316 [Full Text]  
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• Weber, G., Gross, J., Kromminga, A., Loew, H.-H., Eckardt, K.-U. (2002). Allergic Skin and Systemic Reactions in a Patient with Pure Red Cell Aplasia and Anti-Erythropoietin Antibodies Challenged with Different Epoetins. J. Am. Soc. Nephrol. 13: 2381-2383 [Abstract] [Full Text]  
• Mercadal, L., Sutton, L., Casadevall, N., Bagnis, C., Jacobs, C. (2002). Immunological reaction against erythropoietin causing red-cell aplasia. Nephrol Dial Transplant 17: 943-943 [Full Text]  
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• Li, J., Yang, C., Xia, Y., Bertino, A., Glaspy, J., Roberts, M., Kuter, D. J. (2001). Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 98: 3241-3248 [Abstract] [Full Text]  
• Abina, M.-A., Tulliez, M., Duffour, M.-T., Debili, N., Lacout, C., Villeval, J.-L., Wendling, F., Vainchenker, W., Haddada, H. (1998). Thrombopoietin (TPO) Knockout Phenotype Induced by Cross-Reactive Antibodies Against TPO Following Injection of Mice with Recombinant Adenovirus Encoding Human TPO. J. Immunol. 160: 4481-4489 [Abstract] [Full Text]  
• Urra, J. M., Miguel de la Torre, , Alcazar, R., Peces, R. (1997). Rapid Method for Detection of Anti-Recombinant Human Erythropoietin Antibodies as a New Form of Erythropoietin Resistance. Clin. Chem. 43: 848-849 [Full Text]