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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 335:577-584 August 22, 1996 Number 8
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Case 26-1996— A Seven-Year-Old-Boy with Fever, Lymphadenopathy, Hepatosplenomegaly, and Prominent Eosinophilia
Jed B. Gorlin, and Judith A. Ferry

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Presentation of Case

A seven-year-old boy was admitted to the hospital because of fever, lymphadenopathy, hepatosplenomegaly, and eosinophilia.

The boy had been in good health until two months earlier, when fever and disorientation developed. He was taken to another hospital, where a seizure occurred. Meningoencephalitis was diagnosed, antibiotics were administered intravenously, and he received phenytoin and carbamazepine. He recovered and was discharged taking both agents; phenytoin was discontinued after one month.

Two weeks before admission to this hospital, the fever recurred, particularly in the early morning hours; the temperature rose as high as 38.9°C, with anorexia. Eleven days before admission, a physician found . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnosis

Dr. Jed B. Gorlin's Diagnosis

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Related Letters:

Case 26-1996: Hypersensitivity to Carbamazepine
Waagner D. C., Mönkemüller K. E., Jaster J. H., Levy A. M., Gleich G. J., Pichler W. J., Schnyder B., Zanni M., Gorlin J. B.
Extract | Full Text  
N Engl J Med 1997; 336:376-377, Jan 30, 1997. Correspondence

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