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A correction has been published: N Engl J Med 1996;335(21):1619.

Editorial
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Volume 335:659-660 August 29, 1996 Number 9
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Pharmacotherapy for Obesity — Do the Benefits Outweigh the Risks?

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An association between appetite-suppressant drugs and primary pulmonary hypertension is reported by Abenhaim et al. in this issue of the Journal.1 This important finding requires careful assessment, because the prevalence of obesity is increasing and sustained weight reduction has been difficult to achieve without drug treatment. Moreover, the appetite-suppressant drug dexfenfluramine (Redux) has recently become available in the United States. The current receptive climate for pharmacotherapy reflects a paradigm shift: obesity is now recognized as a chronic disease that requires long-term treatment. Obesity results from a complex interaction of genetic, behavioral, and environmental factors. Because exercise, diet, and behavioral . . . [Full Text of this Article]

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