FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 336:28-40 January 2, 1997 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

Intracranial aneurysms are acquired lesions that are most commonly located at the branching points of the major arteries coursing through the subarachnoid space at the base of the brain (Figure 1). A subarachnoid hemorrhage due to the rupture of an intracranial aneurysm is a devastating event associated with high rates of morbidity and mortality. Approximately 12 percent of patients die before receiving medical attention,¹ 40 percent of hospitalized patients die within one month after the event,^2,3,4,5,6 and more than one third of those who survive have major neurologic deficits.^2,3,4,5,6 Furthermore, persistent cognitive deficits are present in many patients . . . [Full Text of this Article]

Epidemiology

Prevalence of Intracranial Aneurysms

Incidence of Subarachnoid Hemorrhage

Pathological Features

Pathogenesis

Genetic Factors

Environmental Factors

Diagnosis

Clinical Presentation

            Subarachnoid Hemorrhage

            Mass Effect

            Cerebral Ischemia

            Asymptomatic Intracranial Aneurysms

Diagnostic Studies

            Subarachnoid Hemorrhage

            Intracranial Aneurysms

Screening

Treatment

Surgery

Endovascular Therapy

Source Information

From the Department of Neurologic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, where reprint requests should be addressed to Dr. Schievink.

References

Related Letters:

Intracranial Aneurysms
Kappos L., Dommasch D., Lipton M., Navarrete P., Shacker P. L., Schievink W. I.
Extract | Full Text  
N Engl J Med 1997; 336:1758-1759, Jun 12, 1997. Correspondence

This article has been cited by other articles:

• Nuki, Y., Tsou, T.-L., Kurihara, C., Kanematsu, M., Kanematsu, Y., Hashimoto, T. (2009). Elastase-Induced Intracranial Aneurysms in Hypertensive Mice. Hypertension 54: 1337-1344 [Abstract] [Full Text]  
• Chien, A., Castro, M.A., Tateshima, S., Sayre, J., Cebral, J., Vinuela, F. (2009). Quantitative Hemodynamic Analysis of Brain Aneurysms at Different Locations. Am. J. Neuroradiol. 30: 1507-1512 [Abstract] [Full Text]  
• DeLeo, M. J. III, Gounis, M. J., Hong, B., Ford, J. C., Wakhloo, A. K., Bogdanov, A. A. Jr (2009). Carotid Artery Brain Aneurysm Model: In Vivo Molecular Enzyme-specific MR Imaging of Active Inflammation in a Pilot Study. Radiology 252: 696-703 [Abstract] [Full Text]  
• Vecchione, C., Frati, A., Di Pardo, A., Cifelli, G., Carnevale, D., Gentile, M. T., Carangi, R., Landolfi, A., Carullo, P., Bettarini, U., Antenucci, G., Mascio, G., Busceti, C. L., Notte, A., Maffei, A., Cantore, G. P., Lembo, G. (2009). Tumor Necrosis Factor-{alpha} Mediates Hemolysis-Induced Vasoconstriction and the Cerebral Vasospasm Evoked by Subarachnoid Hemorrhage. Hypertension 54: 150-156 [Abstract] [Full Text]  
• Meyers, P. M., Schumacher, H. C., Higashida, R. T., Barnwell, S. L., Creager, M. A., Gupta, R., McDougall, C. G., Pandey, D. K., Sacks, D., Wechsler, L. R. (2009). Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures: A Scientific Statement From the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation 119: 2235-2249 [Full Text]  
• Bederson, J. B., Connolly, E. S. Jr, Batjer, H. H., Dacey, R. G., Dion, J. E., Diringer, M. N., Duldner, J. E. Jr, Harbaugh, R. E., Patel, A. B., Rosenwasser, R. H. (2009). Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association. Stroke 40: 994-1025 [Full Text]  
• Cahill, J., Zhang, J. H. (2009). Subarachnoid Hemorrhage: Is It Time for a New Direction?. Stroke 40: S86-S87 [Abstract] [Full Text]  
• Gonzalez, N., Sedrak, M., Martin, N., Vinuela, F. (2008). Impact of Anatomic Features in the Endovascular Embolization of 181 Anterior Communicating Artery Aneurysms. Stroke 39: 2776-2782 [Abstract] [Full Text]  
• Pierot, L., Spelle, L., Vitry, F., for the ATENA Investigators, (2008). Immediate Clinical Outcome of Patients Harboring Unruptured Intracranial Aneurysms Treated by Endovascular Approach: Results of the ATENA Study. Stroke 39: 2497-2504 [Abstract] [Full Text]  
• Madden, M. E (2008). Diagnostic Imaging of Cerebrovascular Injury. radtech 79: 535MR-549MR [Abstract] [Full Text]  
• Gao, L., Hoi, Y., Swartz, D. D., Kolega, J., Siddiqui, A., Meng, H. (2008). Nascent Aneurysm Formation at the Basilar Terminus Induced by Hemodynamics. Stroke 39: 2085-2090 [Abstract] [Full Text]  
• Siao, D., Seetapah, A., Ryman, A., Guerin, V., Mesli, A., Maurette, P. (2008). Optimal Management of an Aneurysmal Subarachnoid Hemorrhage in a Patient With Known Factor XI Deficiency: A Case Report. CLIN APPL THROMB HEMOST 14: 108-111 [Abstract]  
• Trimble, J. L, Kockler, D. R (2007). Statin Treatment of Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage. The Annals of Pharmacotherapy 41: 2019-2023 [Abstract] [Full Text]  
• Priebe, H.-J. (2007). Aneurysmal subarachnoid haemorrhage and the anaesthetist. Br J Anaesth 99: 102-118 [Abstract] [Full Text]  
• Vermeulen, M. J., Schull, M. J. (2007). Missed Diagnosis of Subarachnoid Hemorrhage in the Emergency Department. Stroke 38: 1216-1221 [Abstract] [Full Text]  
• Linfante, I., Wakhloo, A. K. (2007). Brain Aneurysms and Arteriovenous Malformations: Advancements and Emerging Treatments in Endovascular Embolization. Stroke 38: 1411-1417 [Abstract] [Full Text]  
• Higashida, R.T., Lahue, B.J., Torbey, M.T., Hopkins, L.N., Leip, E., Hanley, D.F. (2007). Treatment of Unruptured Intracranial Aneurysms: A Nationwide Assessment of Effectiveness. Am. J. Neuroradiol. 28: 146-151 [Abstract] [Full Text]  
• Shih, H.-C., Lin, C.-L., Lee, T.-Y., Lee, W.-S., Hsu, C. (2006). 17{beta}-Estradiol Inhibits Subarachnoid Hemorrhage-Induced Inducible Nitric Oxide Synthase Gene Expression by Interfering With the Nuclear Factor {kappa}B Transactivation. Stroke 37: 3025-3031 [Abstract] [Full Text]  
• Perry, J. J., Sivilotti, M. L.A., Stiell, I. G., Wells, G. A., Raymond, J., Mortensen, M., Symington, C. (2006). Should Spectrophotometry Be Used to Identify Xanthochromia in the Cerebrospinal Fluid of Alert Patients Suspected of Having Subarachnoid Hemorrhage?. Stroke 37: 2467-2472 [Abstract] [Full Text]  
• Brisman, J. L., Song, J. K., Newell, D. W. (2006). Cerebral aneurysms.. NEJM 355: 928-939 [Full Text]  
• Bourekas, E.C., Newton, H.B., Figg, G.M., Slone, H.W. (2006). Prevalence and Rupture Rate of Cerebral Aneurysms Discovered during Intra-Arterial Chemotherapy of Brain Tumors.. Am. J. Neuroradiol. 27: 297-299 [Abstract] [Full Text]  
• Banki, N. M., Kopelnik, A., Dae, M. W., Miss, J., Tung, P., Lawton, M. T., Drew, B. J., Foster, E., Smith, W., Parmley, W. W., Zaroff, J. G. (2005). Acute Neurocardiogenic Injury After Subarachnoid Hemorrhage. Circulation 112: 3314-3319 [Abstract] [Full Text]  
• Feigin, V., Parag, V., Lawes, C. M. M., Rodgers, A., Suh, I., Woodward, M., Jamrozik, K., Ueshima, H., on behalf of the Asia Pacific Cohort Studies Colla, (2005). Smoking and Elevated Blood Pressure Are the Most Important Risk Factors for Subarachnoid Hemorrhage in the Asia-Pacific Region: An Overview of 26 Cohorts Involving 306 620 Participants. Stroke 36: 1360-1365 [Abstract] [Full Text]  
• Pluta, R. M., Dejam, A., Grimes, G., Gladwin, M. T., Oldfield, E. H. (2005). Nitrite Infusions to Prevent Delayed Cerebral Vasospasm in a Primate Model of Subarachnoid Hemorrhage. JAMA 293: 1477-1484 [Abstract] [Full Text]  
• Roos, Y.B.W.E.M., Pals, G., Struycken, P.M., Rinkel, G.J.E., Limburg, M., Pronk, J.C., van den Berg, J.S.P., Luijten, J.A.F.M., Pearson, P.L., Vermeulen, M., Westerveld, A. (2004). Genome-Wide Linkage in a Large Dutch Consanguineous Family Maps a Locus for Intracranial Aneurysms to Chromosome 2p13. Stroke 35: 2276-2281 [Abstract] [Full Text]  
• Locker, T, Mason, S, Rigby, A (2004). Headache management--Are we doing enough? An observational study of patients presenting with headache to the emergency department. Emerg. Med. J. 21: 327-332 [Abstract] [Full Text]  
• Gaist, D., Pedersen, L., Cnattingius, S., Sorensen, H. T. (2004). Parity and Risk of Subarachnoid Hemorrhage in Women: A Nested Case-Control Study Based on National Swedish Registries. Stroke 35: 28-32 [Abstract] [Full Text]  
• Khurana, V. G., Sohni, Y. R., Mangrum, W. I., McClelland, R. L., O'Kane, D. J., Meyer, F. B., Meissner, I. (2003). Endothelial Nitric Oxide Synthase T-786C Single Nucleotide Polymorphism: A Putative Genetic Marker Differentiating Small Versus Large Ruptured Intracranial Aneurysms. Stroke 34: 2555-2559 [Abstract] [Full Text]  
• Stahl, J. E., Furie, K. L., Gleason, S., Gazelle, G. S. (2003). Stroke: Effect of Implementing an Evaluation and Treatment Protocol Compliant with NINDS Recommendations. Radiology 228: 659-668 [Abstract] [Full Text]  
• Vogel, T., Verreault, R., Turcotte, J.-F., Kiesmann, M., Berthel, M. (2003). Review Article. Intracerebral Aneurysms: A Review With Special Attention to Geriatric Aspects. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58: M520-524 [Abstract] [Full Text]  
• Wills, S., Ronkainen, A., van der Voet, M., Kuivaniemi, H., Helin, K., Leinonen, E., Frosen, J., Niemela, M., Jaaskelainen, J., Hernesniemi, J., Tromp, G. (2003). Familial Intracranial Aneurysms: An Analysis of 346 Multiplex Finnish Families. Stroke 34: 1370-1374 [Abstract] [Full Text]  
• Mallouhi, A., Felber, S., Chemelli, A., Dessl, A., Auer, A., Schocke, M., Jaschke, W. R., Waldenberger, P. (2003). Detection and Characterization of Intracranial Aneurysms with MR Angiography: Comparison of Volume-Rendering and Maximum-Intensity-Projection Algorithms. Am. J. Roentgenol. 180: 55-64 [Abstract] [Full Text]  
• Johnston, S. C., Higashida, R. T., Barrow, D. L., Caplan, L. R., Dion, J. E., Hademenos, G., Hopkins, L. N., Molyneux, A., Rosenwasser, R. H., Vinuela, F., Wilson, C. B. (2002). Recommendations for the Endovascular Treatment of Intracranial Aneurysms: A Statement for Healthcare Professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular Radiology. Stroke 33: 2536-2544 [Full Text]  
• Thrift, A. G., Donnan, G. A. (2002). RE: "DOES TEA AFFECT CARDIOVASCULAR DISEASE? A META-ANALYSIS". Am J Epidemiol 156: 490-490 [Full Text]  
• Kirkpatrick, P J (2002). SUBARACHNOID HAEMORRHAGE AND INTRACRANIAL ANEURYSMS: WHAT NEUROLOGISTS NEED TO KNOW. J. Neurol. Neurosurg. Psychiatry 73: i28-33 [Full Text]  
• Leclerc, X., Navez, J.-F., Gauvrit, J.-Y., Lejeune, J.-P., Pruvo, J.-P. (2002). Aneurysms of the Anterior Communicating Artery Treated with Guglielmi Detachable Coils: Follow-Up with Contrast-Enhanced MR Angiography. Am. J. Neuroradiol. 23: 1121-1127 [Abstract] [Full Text]  
• Bardach, N. S., Zhao, S., Gress, D. R., Lawton, M. T., Johnston, S. C., Fisher, W. S. III (2002). Association Between Subarachnoid Hemorrhage Outcomes and Number of Cases Treated at California Hospitals * Editorial Comment. Stroke 33: 1851-1856 [Abstract] [Full Text]  
• Pirson, Y., Chauveau, D., Torres, V. (2002). Management of Cerebral Aneurysms in Autosomal Dominant Polycystic Kidney Disease. J. Am. Soc. Nephrol. 13: 269-276 [Full Text]  
• Ronkainen, A., Niskanen, M., Rinne, J., Koivisto, T., Hernesniemi, J., Vapalahti, M. (2001). Evidence for Excess Long-Term Mortality After Treated Subarachnoid Hemorrhage. Stroke 32: 2850-2853 [Abstract] [Full Text]  
• Johnston, S. C. (2001). Identifying Confounding by Indication through Blinded Prospective Review. Am J Epidemiol 154: 276-284 [Abstract] [Full Text]  
• Thrift, A. G., Dewey, H. M., Macdonell, R. A.L., McNeil, J. J., Donnan, G. A. (2001). Incidence of the Major Stroke Subtypes: Initial Findings From the North East Melbourne Stroke Incidence Study (NEMESIS). Stroke 32: 1732-1738 [Abstract] [Full Text]  
• Johnson, M. R, Good, C. D, Penny, W. D, Barnes, P. R., Scadding, J. W (2001). Lesson of the week: Playing the odds in clinical decision making: lessons from berry aneurysms undetected by magnetic resonance angiography. BMJ 322: 1347-1349 [Full Text]  
• Fassbender, K, Hodapp, B, Rossol, S, Bertsch, T, Schmeck, J, Schutt, S, Fritzinger, M, Horn, P, Vajkoczy, P, Kreisel, S, Brunner, J, Schmiedek, P, Hennerici, M (2001). Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J. Neurol. Neurosurg. Psychiatry 70: 534-537 [Abstract] [Full Text]  
• Triantafillidi, H., Rizos, I., Androulakis, A., Stratos, K., Arvaniti, C., Toutouzas, P. (2001). Coronary Artery Ectasia, Aneurysm of the Basilar Artery and Varicose Veins: Common Presentation or Generalized Defect of the Vessel Wall?: A Case Report. ANGIOLOGY 52: 287-291 [Abstract]  
• Eskey an, C. J., Ogilvy, C. S. (2001). Fluoroscopy-guided Lumbar Puncture: Decreased Frequency of Traumatic Tap and Implications for the Assessment of CT-negative Acute Subarachnoid Hemorrhage. Am. J. Neuroradiol. 22: 571-576 [Abstract] [Full Text]  
• Mhurchu, C. N., Anderson, C., Jamrozik, K., Hankey, G., Dunbabin, D., Longstreth, W.T. Jr, Nelson, L. M. (2001). Hormonal Factors and Risk of Aneurysmal Subarachnoid Hemorrhage : An International Population-Based, Case-Control Study Editorial Comment : The Gender Gap in Aneurysmal Subarachnoid Hemorrhage. Stroke 32: 606-612 [Abstract] [Full Text]  
• Touze, E., Randoux, B., Meary, E., Arquizan, C., Meder, J.-F., Mas, J.-L. (2001). Aneurysmal Forms of Cervical Artery Dissection : Associated Factors and Outcome. Stroke 32: 418-423 [Abstract] [Full Text]  
• Fa{beta}bender, K., Hodapp, B., Rossol, S., Bertsch, T., Schmeck, J., Schutt, S., Fritzinger, M., Horn, P., Vajkoczy, P., Wendel-Wellner, M., Ragoschke, A., Kuehl, S., Brunner, J., Schurer, L., Schmiedeck, P., Hennerici, M. (2000). Endothelin-1 in Subarachnoid Hemorrhage : An Acute-Phase Reactant Produced by Cerebrospinal Fluid Leukocytes. Stroke 31: 2971-2975 [Abstract] [Full Text]  
• Koivisto, T., Vanninen, R., Hurskainen, H., Saari, T., Hernesniemi, J., Vapalahti, M. (2000). Outcomes of Early Endovascular Versus Surgical Treatment of Ruptured Cerebral Aneurysms : A Prospective Randomized Study. Stroke 31: 2369-2377 [Abstract] [Full Text]  
• Hackett, M. L., Anderson, C. S. (2000). Health outcomes 1 year after subarachnoid hemorrhage: An international population-based study. Neurology 55: 658-662 [Abstract] [Full Text]  
• Turner, C. L, Kirkpatrick, P. J (2000). Detection of intracranial aneurysms with unenhanced and echo contrast enhanced transcranial power Doppler. J. Neurol. Neurosurg. Psychiatry 68: 489-495 [Abstract] [Full Text]  
• Gaist, D., Væth, M., Tsiropoulos, I., Christensen, K., Corder, E., Olsen, J., Sørensen, H. T. (2000). Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage: follow up study based on national registries in Denmark. BMJ 320: 141-145 [Abstract] [Full Text]  
• Edlow, J. A., Caplan, L. R. (2000). Avoiding Pitfalls in the Diagnosis of Subarachnoid Hemorrhage. NEJM 342: 29-36 [Full Text]  
• Kirkpatrick, P. J, McConnell, R S (1999). Screening for familial intracranial aneurysms. BMJ 319: 1512-1513 [Full Text]  
• Willinsky, R. A. (1999). Detachable coils to treat intracranial aneurysms. CMAJ 161: 1136-1136 [Full Text]  
• Mariani, L., Bianchetti, M. G., Schroth, G., Seiler, R. W. (1999). Cerebral aneurysms in patients with autosomal dominant polycystic kidney disease—to screen, to clip, to coil?. Nephrol Dial Transplant 14: 2319-2322 [Full Text]  
• Johnston, S. C., Dudley, R. A., Gress, D. R., Ono, L. (1999). Surgical and endovascular treatment of unruptured cerebral aneurysms at university hospitals. Neurology 52: 1799-1799 [Abstract] [Full Text]  
• Vanninen, R., Koivisto, T., Saari, T., Hernesniemi, J., Vapalahti, M. (1999). Ruptured Intracranial Aneurysms: Acute Endovascular Treatment with Electrolytically Detachable Coils—A Prospective Randomized Study. Radiology 211: 325-336 [Abstract] [Full Text]  
• Chang, S. D, Steinberg, G. K (1998). Management of intracranial aneurysms. Vasc Med 3: 315-326 [Abstract]  
• Gilman, S. (1998). Imaging the Brain- First of Two Parts. NEJM 338: 812-820 [Full Text]  
• Litchfield, W. R., Anderson, B. F., Weiss, R. J., Lifton, R. P., Dluhy, R. G. (1998). Intracranial Aneurysm and Hemorrhagic Stroke in Glucocorticoid-remediable Aldosteronism. Hypertension 31: 445-450 [Abstract] [Full Text]  
• Kappos, L., Dommasch, D., Lipton, M., Navarrete, P., Shacker, P. L., Schievink, W. I. (1997). Intracranial Aneurysms. NEJM 336: 1758-1759 [Full Text]