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Previous Volume 336:732-733 March 6, 1997 Number 10 Next

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To the Editor: Severe infections with varicella–zoster virus are common in immunocompromised hosts.¹ Hemorrhagic varicella is serious and frequently fatal. We describe a case of hemorrhagic varicella that was resistant to a conventional regimen of acyclovir but was successfully treated by a continuous infusion of acyclovir.

A 40-year-old woman with leukemia treated with various chemotherapies was admitted with fever, general fatigue, and generalized hemorrhagic bullae without a dermatomic distribution (Figure 1A and Figure 1B). A Tzanck smear of the bullae was positive. The patient had had varicella in childhood. An intravenous infusion of 250 mg of acyclovir over . . . [Full Text of this Article]

References

Related Letters:

More on Continuous-Infusion Acyclovir for Severe Varicella
Krolewiecki A. J., Braffman M., Kakinuma H., Itoh E.
Extract | Full Text  
N Engl J Med 1997; 337:203-204, Jul 17, 1997. Correspondence

This article has been cited by other articles:

• Krolewiecki, A. J., Braffman, M., Kakinuma, H., Itoh, E. (1997). More on Continuous-Infusion Acyclovir for Severe Varicella. NEJM 337: 203-204 [Full Text]