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Previous Volume 336:734 March 6, 1997 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In our article on germ-line mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms (May 14, 1992, issue),¹ we reported that the proband (II-1) and her mother (I-2) in Family 6 carried germ-line point mutations in the p53 gene that resulted in an amino acid change from arginine to tryptophan at codon 248 (Figure 1 and Figure 3). The proband's father and sister were reported to carry wild-type p53. As part of a clinical program of genetic testing, a second p53 analysis was performed on a new blood specimen from the . . . [Full Text of this Article]

References

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• Evans, D G R, Birch, J M, Thorneycroft, M, McGown, G, Lalloo, F, Varley, J M (2002). Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome. J. Med. Genet. 39: 941-944 [Full Text]