The Management of Hypertrophic Cardiomyopathy

doi:10.1056/NEJM199703133361107

Volume 336:775-785		March 13, 1997		Number 11

The Management of Hypertrophic Cardiomyopathy

Paolo Spirito, M.D., Christine E. Seidman, M.D., William J. McKenna, M.D., and Barry J. Maron, M.D.

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Hypertrophic cardiomyopathy is a complex cardiac disease withunique pathophysiologic characteristics and a great diversityof morphologic, functional, and clinical features.¹^,²^,³^,⁴^,⁵^,⁶^,⁷^,⁸The heterogeneity of the disease is accentuated by the factthat it afflicts patients of all ages. During the past few years,technological developments in implantable defibrillators andpacemakers have provided new therapeutic options for patientswith the disease.⁹^,¹⁰^,¹¹^,¹²^,¹³^,¹⁴^,¹⁵^,¹⁶^,¹⁷^,¹⁸ In addition, rapidadvances in our knowledge of the molecular defects responsiblefor hypertrophic cardiomyopathy have deepened our understandingof the disorder and have suggested new approaches to the assessmentof prognosis.¹⁹^,²⁰^,²¹^,²² These recent developments, however,have also generated considerable . . . [Full Text of this Article]

Heterogeneity of Clinical and Genetic Features

Treatment of the Symptoms of Heart Failure

Medical Therapy

Pharmacologic Options

Strategies for Drug Therapy

Treatment of Asymptomatic Patients and Prevention of Disease Progression

Management of Atrial Fibrillation

Treatment Options after the Failure of Drug Therapy

Surgery for Relief of Outflow Tract Obstruction and Symptoms

Nonsurgical Techniques for Relief of Outflow Tract Obstruction and Symptoms

Stratification of Risk

Clinical Indicators of Risk

Major Risk Factors

Electrophysiologic Testing

Syncope

Massive Left Ventricular Hypertrophy

Genetic Indicators of Risk

Prevention of Sudden Death

Amiodarone

Implantable Defibrillators

Source Information

From the Servizio di Cardiologia, Ospedale Sant'Andrea, La Spezia, Italy (P.S.); the Howard Hughes Medical Institute and the Cardiovascular Division, Brigham and Women's Hospital, Boston (C.E.S.); the Department of Cardiological Sciences, St. George's Hospital Medical School, London (W.J.M.); and the Minneapolis Heart Institute Foundation, Minneapolis (B.J.M.).

Address reprint requests to Dr. Spirito at the Servizio di Cardiologia, Ospedale Sant'Andrea, Via Veneto 197, La Spezia 19100, Italy.

References

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The Management of Hypertrophic Cardiomyopathy
Seggewiss H., Gleichmann U., Faber L., Maron B. J., Spirito P., McKenna W. J., Seidman C. E.
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N Engl J Med 1997; 337:349-350, Jul 31, 1997. Correspondence

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Williams, L., Frenneaux, M. (2007). Syncope in hypertrophic cardiomyopathy: mechanisms and consequences for treatment. Europace 9: 817-822 [Abstract] [Full Text]
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Kubo, T., Gimeno, J. R., Bahl, A., Steffensen, U., Steffensen, M., Osman, E., Thaman, R., Mogensen, J., Elliott, P. M., Doi, Y., McKenna, W. J. (2007). Prevalence, Clinical Significance, and Genetic Basis of Hypertrophic Cardiomyopathy With Restrictive Phenotype. J Am Coll Cardiol 49: 2419-2426 [Abstract] [Full Text]
Petersen, S. E., Jerosch-Herold, M., Hudsmith, L. E., Robson, M. D., Francis, J. M., Doll, H. A., Selvanayagam, J. B., Neubauer, S., Watkins, H. (2007). Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy: New Insights From Multiparametric Magnetic Resonance Imaging. Circulation 115: 2418-2425 [Abstract] [Full Text]
Barrick, C. J., Rojas, M., Schoonhoven, R., Smyth, S. S., Threadgill, D. W. (2007). Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 292: H2119-H2130 [Abstract] [Full Text]
Maron, M. S., Olivotto, I., Zenovich, A. G., Link, M. S., Pandian, N. G., Kuvin, J. T., Nistri, S., Cecchi, F., Udelson, J. E., Maron, B. J. (2006). Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction. Circulation 114: 2232-2239 [Abstract] [Full Text]
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Crump, S. M., Correll, R. N., Schroder, E. A., Lester, W. C., Finlin, B. S., Andres, D. A., Satin, J. (2006). L-type calcium channel {alpha}-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. Am. J. Physiol. Heart Circ. Physiol. 291: H1959-H1971 [Abstract] [Full Text]
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Zipes, D. P., Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA (Practice Guidelines) Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society.. Eur Heart J 27: 2099-2140 [Full Text]
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Elliott, P. M., Gimeno, J. R., Tome, M. T., Shah, J., Ward, D., Thaman, R., Mogensen, J., McKenna, W. J. (2006). Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. Eur Heart J 27: 1933-1941 [Abstract] [Full Text]
D'Andrea, A., Caso, P., Severino, S., Cuomo, S., Capozzi, G., Calabro, P., Cice, G., Ascione, L., Scherillo, M., Calabro, R. (2006). Prognostic value of intra-left ventricular electromechanical asynchrony in patients with hypertrophic cardiomyopathy. Eur Heart J 27: 1311-1318 [Abstract] [Full Text]
Spirito, P., Autore, C. (2006). Management of hypertrophic cardiomyopathy.. BMJ 332: 1251-1255 [Full Text]
Yoerger, D. M., Best, C. A., McQuillan, B. M., Supple, G. E., Guererro, J. L., Cluette-Brown, J. E., Hasaba, A., Picard, M. H., Stone, J. R., Laposata, M. (2006). Rapid Fatty Acid Ethyl Ester Synthesis by Porcine Myocardium Upon Ethanol Infusion into the Left Anterior Descending Coronary Artery. Am. J. Pathol. 168: 1435-1442 [Abstract] [Full Text]
D'Andrea, A, Caso, P, Cuomo, S, Salerno, G, Scarafile, R, Mita, C, De Corato, G, Sarubbi, B, Scherillo, M, Calabro, R, Citro, R (2006). Prognostic value of intra-left ventricular electromechanical asynchrony in patients with mild hypertrophic cardiomyopathy compared with power athletes * Commentary.. Br. J. Sports. Med. 40: 244-250 [Abstract] [Full Text]
Strickberger, S. A., Benson, D. W., Biaggioni, I., Callans, D. J., Cohen, M. I., Ellenbogen, K. A., Epstein, A. E., Friedman, P., Goldberger, J., Heidenreich, P. A., Klein, G. J., Knight, B. P., Morillo, C. A., Myerburg, R. J., Sila, C. A. (2006). AHA/ACCF Scientific Statement on the Evaluation of Syncope: From the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research Interdisciplinary Working Group; and the American College of Cardiology Foundation In Collaboration With the Heart Rhythm Society. J Am Coll Cardiol 47: 473-484 [Full Text]
Strickberger, S. A., Benson, D. W., Biaggioni, I., Callans, D. J., Cohen, M. I., Ellenbogen, K. A., Epstein, A. E., Friedman, P., Goldberger, J., Heidenreich, P. A., Klein, G. J., Knight, B. P., Morillo, C. A., Myerburg, R. J., Sila, C. A. (2006). AHA/ACCF Scientific Statement on the Evaluation of Syncope: From the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research Interdisciplinary Working Group; and the American College of Cardiology Foundation: In Collaboration With the Heart Rhythm Society: Endorsed by the American Autonomic Society. Circulation 113: 316-327 [Full Text]
Perkins, M. J., Van Driest, S. L., Ellsworth, E. G., Will, M. L., Gersh, B. J., Ommen, S. R., Ackerman, M. J. (2005). Gene-specific modifying effects of pro-LVH polymorphisms involving the renin-angiotensin-aldosterone system among 389 unrelated patients with hypertrophic cardiomyopathy. Eur Heart J 26: 2457-2462 [Abstract] [Full Text]
Kubo, T., Kitaoka, H., Okawa, M., Matsumura, Y., Hitomi, N., Yamasaki, N., Furuno, T., Takata, J., Nishinaga, M., Kimura, A., Doi, Y. L. (2005). Lifelong Left Ventricular Remodeling of Hypertrophic Cardiomyopathy Caused by a Founder Frameshift Deletion Mutation in the Cardiac Myosin-Binding Protein C Gene Among Japanese. J Am Coll Cardiol 46: 1737-1743 [Abstract] [Full Text]
Biagini, E., Coccolo, F., Ferlito, M., Perugini, E., Rocchi, G., Bacchi-Reggiani, L., Lofiego, C., Boriani, G., Prandstraller, D., Picchio, F. M., Branzi, A., Rapezzi, C. (2005). Dilated-Hypokinetic Evolution of Hypertrophic Cardiomyopathy: Prevalence, Incidence, Risk Factors, and Prognostic Implications in Pediatric and Adult Patients. J Am Coll Cardiol 46: 1543-1550 [Abstract] [Full Text]
Ingles, J, Doolan, A, Chiu, C, Seidman, J, Seidman, C, Semsarian, C (2005). Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. J. Med. Genet. 42: e59-e59 [Abstract] [Full Text]
Binder, W. D., Fifer, M. A., King, M. E., Stone, J. R. (2005). Case 26-2005 - A 48-Year-Old Man with Sudden Loss of Consciousness while Jogging. NEJM 353: 824-832 [Full Text]
Ommen, S. R., Maron, B. J., Olivotto, I., Maron, M. S., Cecchi, F., Betocchi, S., Gersh, B. J., Ackerman, M. J., McCully, R. B., Dearani, J. A., Schaff, H. V., Danielson, G. K., Tajik, A. J., Nishimura, R. A. (2005). Long-Term Effects of Surgical Septal Myectomy on Survival in Patients With Obstructive Hypertrophic Cardiomyopathy. J Am Coll Cardiol 46: 470-476 [Abstract] [Full Text]
Mahrholdt, H., Wagner, A., Judd, R. M., Sechtem, U., Kim, R. J. (2005). Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J 26: 1461-1474 [Abstract] [Full Text]
van der Lee, C., ten Cate, F. J., Geleijnse, M. L., Kofflard, M. J., Pedone, C., van Herwerden, L. A., Biagini, E., Vletter, W. B., Serruys, P. W. (2005). Percutaneous Versus Surgical Treatment for Patients With Hypertrophic Obstructive Cardiomyopathy and Enlarged Anterior Mitral Valve Leaflets. Circulation 112: 482-488 [Abstract] [Full Text]
Autore, C., Bernabo, P., Barilla, C. S., Bruzzi, P., Spirito, P. (2005). The prognostic importance of left ventricular outflow obstruction in hypertrophic cardiomyopathy varies in relation to the severity of symptoms. J Am Coll Cardiol 45: 1076-1080 [Abstract] [Full Text]
Wall, M., Calvert, C. A., Sanderson, S. L., Leonhardt, A., Barker, C., Fallaw, T. K. (2005). Evaluation of Extended-Release Diltiazem Once Daily for Cats With Hypertrophic Cardiomyopathy. Journal of the American Animal Hospital Association 41: 98-103 [Abstract] [Full Text]
Adabag, A. S., Casey, S. A., Kuskowski, M. A., Zenovich, A. G., Maron, B. J. (2005). Spectrum and prognostic significance of arrhythmias on ambulatory Holter electrocardiogram in hypertrophic cardiomyopathy. J Am Coll Cardiol 45: 697-704 [Abstract] [Full Text]
Arad, M., Maron, B. J., Gorham, J. M., Johnson, W. H. Jr., Saul, J. P., Perez-Atayde, A. R., Spirito, P., Wright, G. B., Kanter, R. J., Seidman, C. E., Seidman, J.G. (2005). Glycogen Storage Diseases Presenting as Hypertrophic Cardiomyopathy. NEJM 352: 362-372 [Abstract] [Full Text]
Kaufmann, P. A., Camici, P. G. (2005). Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications. JNM 46: 75-88 [Full Text]
Maron, B. J., Dearani, J. A., Ommen, S. R., Maron, M. S., Schaff, H. V., Gersh, B. J., Nishimura, R. A. (2004). The case for surgery in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 44: 2044-2053 [Abstract] [Full Text]
Boriani, G., Maron, B. J., Shen, W.-K., Spirito, P. (2004). Prevention of Sudden Death in Hypertrophic Cardiomyopathy: But Which Defibrillator for Which Patient?. Circulation 110: e438-e442 [Full Text]
Wernicke, D., Thiel, C., Duja-Isac, C. M., Essin, K. V., Spindler, M., Nunez, D. J. R., Plehm, R., Wessel, N., Hammes, A., Edwards, R.-J., Lippoldt, A., Zacharias, U., Stromer, H., Neubauer, S., Davies, M. J., Morano, I., Thierfelder, L. (2004). {alpha}-Tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287: R685-R695 [Abstract] [Full Text]
Murata, M., Cingolani, E., McDonald, A. D., Donahue, J. K., Marban, E. (2004). Creation of a Genetic Calcium Channel Blocker by Targeted Gem Gene Transfer in the Heart. Circ. Res. 95: 398-405 [Abstract] [Full Text]
Van Driest, S. L., Jaeger, M. A., Ommen, S. R., Will, M. L., Gersh, B. J., Tajik, A. J., Ackerman, M. J. (2004). Comprehensive analysis of the beta-myosin heavy chain gene in 389 unrelated patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 44: 602-610 [Abstract] [Full Text]
Task Force Members, , Lopez-Sendo, J., Swedberg, K., McMurray, J., Tamargo, J., Maggioni, A. P., Dargie, H., Tendera, M., Waagstein, F., Kjekshus, J., Lechat, P., Pedersen, C. T., ESC Committee for Practice Guidelines, , Priori, S. G., Alonso Garcia, M. A., Blanc, J.-J., Budaj, A., Cowie, M., Dean, V., Deckers, J., Fernandez Burgos, E., Lekakis, J., Lindahl, B., Mazzotta, G., McGregor, K., Morais, J., Oto, A., Smiseth, O. A., Document Reviewers, , Alonso Garcia, M. A., Ardissino, D., Avendano, C., Lundqvist, C. B., ment, D. C., Drexler, H., Ferrari, R., Fox, K. A., Julian, D., Kearney, P., Klein, W., ber, L. K., Mancia, G., Nieminen, M., Ruzyllo, W., Simoons, M., Thygesen, K., Tognoni, G., Tritto, I., Wallentin, L. (2004). Expert consensus document on {beta}-adrenergic receptor blockers: The Task Force on Beta-Blockers of the European Society of Cardiology. Eur Heart J 25: 1341-1362 [Full Text]
Tong, C. W., Gaffin, R. D., Zawieja, D. C., Muthuchamy, M. (2004). Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics. J. Physiol. 558: 927-941 [Abstract] [Full Text]
Borer, J. S. (2004). Left ventricular hypertrophy in hypertrophic cardiomyopathy: What's in a phenotype?. J Am Coll Cardiol 44: 406-408 [Full Text]
Gietzen, F H, Leuner, C J, Obergassel, L, Strunk-Mueller, C, Kuhn, H (2004). Transcoronary ablation of septal hypertrophy for hypertrophic obstructive cardiomyopathy: feasibility, clinical benefit, and short term results in elderly patients. Heart 90: 638-644 [Abstract] [Full Text]
Flashman, E., Redwood, C., Moolman-Smook, J., Watkins, H. (2004). Cardiac Myosin Binding Protein C: Its Role in Physiology and Disease. Circ. Res. 94: 1279-1289 [Abstract] [Full Text]
Wever, E. F. D., Robles de Medina, E. O. (2004). Sudden death in patients without structural heart disease. J Am Coll Cardiol 43: 1137-1144 [Abstract] [Full Text]
Nishimura, R. A., Holmes, D. R. Jr. (2004). Hypertrophic Obstructive Cardiomyopathy. NEJM 350: 1320-1327 [Full Text]
van Dockum, W. G., ten Cate, F. J., ten Berg, J. M., Beek, A. M., Twisk, J. W. R., Vos, J., Hofman, M. B. M., Visser, C. A., van Rossum, A. C. (2004). Myocardial infarction after percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy: evaluation by contrast-enhanced magnetic resonance imaging. J Am Coll Cardiol 43: 27-34 [Abstract] [Full Text]
Opfermann, U.T., Doll, N., Walther, T., Mohr, F.W. (2003). Combined mitral valve repair, LVOT myectomy and left atrial cryoablation therapy. ICVTS 2: 501-502 [Abstract] [Full Text]
Rovner, A., Smith, R., Greenberg, N. L., Tuzcu, E. M., Smedira, N., Lever, H. M., Thomas, J. D., Garcia, M. J. (2003). Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction. Am. J. Physiol. Heart Circ. Physiol. 285: H2492-H2499 [Abstract] [Full Text]
Sorajja, P., Ommen, S. R., Nishimura, R. A., Gersh, B. J., Berger, P. B., Tajik, A. J. (2003). Adverse Prognosis of Patients With Hypertrophic Cardiomyopathy Who Have Epicardial Coronary Artery Disease. Circulation 108: 2342-2348 [Abstract] [Full Text]
Maron, B. J., McKenna, W. J., Danielson, G. K., Kappenberger, L. J., Kuhn, H. J., Seidman, C. E., Shah, P. M., Spencer, W. H. III, Spirito, P., Ten Cate, F. J., Wigle, E. D., Vogel, R. A., Abrams, J., Bates, E. R., Brodie, B. R., Danias, P. G., Gregoratos, G., Hlatky, M. A., Hochman, J. S., Kaul, S., Lichtenberg, R. C., Lindner, J. R., O'rourke, R. A., Pohost, G. M., Schofield, R. S., Tracy, C. M., Winters, W. L. Jr, Klein, W. W., Priori, S. G., Alonso-Garcia, A., Blomstrom-Lundqvist, C., De Backer, G., Deckers, J., Flather, M., Hradec, J., Oto, A., Parkhomenko, A., Silber, S., Torbicki, A. (2003). American College of Cardiology/European Society of Cardiology Clinical Expert Consensus Document on Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines. J Am Coll Cardiol 42: 1687-1713 [Full Text]
Writing Committee Members, , Maron, B. J., McKenna, W. J., Danielson, G. K., Kappenberger, L. J., Kuhn, H. J., Seidman, C. E., Shah, P. M., Spencer, W. H. III, Spirito, P., Ten Cate, F. J., Wigle, E. D., ACCF Task Force on Clinical Expert Consensus Docum, , Vogel, R. A., Abrams, J., Bates, E. R., Brodie, B. R., Danias, P. G., Gregoratos, G., Hlatky, M. A., Hochman, J. S., Kaul, S., Lichtenberg, R. C., Lindner, J. R., O'Rourke, R. A., Pohost, G. M., Schofield, R. S., Tracy, C. M., Winters, W. L. Jr, ESC Committee for Practice Guidelines Members, , Klein, W. W., Priori, S. G., Alonso-Garcia, A., Blomstrom-Lundqvist, C., De Backer, G., Deckers, J., Flather, M., Hradec, J., Oto, A., Parkhomenko, A., Silber, S., Torbicki, A. (2003). American College of Cardiology/European Society of Cardiology Clinical Expert Consensus Document on Hypertrophic Cardiomyopathy: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines. Eur Heart J 24: 1965-1991 [Full Text]
Antezano, E. S., Hong, M. (2003). Sudden Cardiac Death. J Intensive Care Med 18: 313-329 [Abstract]
van der Lee, C., Kofflard, M. J.M., van Herwerden, L. A., Vletter, W. B., ten Cate, F. J. (2003). Sustained Improvement After Combined Anterior Mitral Leaflet Extension and Myectomy in Hypertrophic Obstructive Cardiomyopathy. Circulation 108: 2088-2092 [Abstract] [Full Text]
Cecchi, F., Olivotto, I., Gistri, R., Lorenzoni, R., Chiriatti, G., Camici, P. G. (2003). Coronary Microvascular Dysfunction and Prognosis in Hypertrophic Cardiomyopathy. NEJM 349: 1027-1035 [Abstract] [Full Text]
Monserrat, L., Elliott, P. M., Gimeno, J. R., Sharma, S., Penas-Lado, M., McKenna, W. J. (2003). Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent marker of sudden death risk in young patients. J Am Coll Cardiol 42: 873-879 [Abstract] [Full Text]
Maron, B. J., Casey, S. A., Hauser, R. G., Aeppli, D. M. (2003). Clinical course of hypertrophiccardiomyopathy with survival to advanced age. J Am Coll Cardiol 42: 882-888 [Abstract] [Full Text]
Schmitt, J. P., Semsarian, C., Arad, M., Gannon, J., Ahmad, F., Duffy, C., Lee, R. T., Seidman, C. E., Seidman, J.G. (2003). Consequences of Pressure Overload on Sarcomere Protein Mutation-Induced Hypertrophic Cardiomyopathy. Circulation 108: 1133-1138 [Abstract] [Full Text]
Van Driest, S. L., Ellsworth, E. G., Ommen, S. R., Tajik, A. J., Gersh, B. J., Ackerman, M. J. (2003). Prevalence and Spectrum of Thin Filament Mutations in an Outpatient Referral Population With Hypertrophic Cardiomyopathy * Note Added in Proof. Circulation 108: 445-451 [Abstract] [Full Text]
Chang, S. M., Nagueh, S. F., Spencer, W. H. III, Lakkis, N. M. (2003). Complete heart block: determinants and clinical impact in patients with hypertrophic obstructive cardiomyopathy undergoing nonsurgical septal reduction therapy. J Am Coll Cardiol 42: 296-300 [Abstract] [Full Text]
Firoozi, S, Sharma, S, McKenna, W J (2003). Risk of competitive sport in young athletes with heart disease. Heart 89: 710-714 [Abstract] [Full Text]
Sato, Y, Taniguchi, R, Nagai, K, Makiyama, T, Okada, H, Yamada, T, Matsumori, A, Takatsu, Y (2003). Measurements of cardiac troponin T in patients with hypertrophic cardiomyopathy. Heart 89: 659-660 [Full Text]
Saumarez, R. C., Chojnowska, L., Derksen, R., Pytkowski, M., Sterlinski, M., Huang, C. L.-H., Sadoul, N., Hauer, R. N.W., Ruzyllo, W., Grace, A. A. (2003). Sudden Death in Noncoronary Heart Disease Is Associated With Delayed Paced Ventricular Activation. Circulation 107: 2595-2600 [Abstract] [Full Text]
Moon, J. C. C., McKenna, W. J., McCrohon, J. A., Elliott, P. M., Smith, G. C., Pennell, D. J. (2003). Toward clinical risk assessment inhypertrophic cardiomyopathy withgadolinium cardiovascular magnetic resonance. J Am Coll Cardiol 41: 1561-1567 [Abstract] [Full Text]

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