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Previous Volume 336:839-845 March 20, 1997 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia and a chronic progressive neurologic disease, HTLV-I–associated myelopathy–tropical spastic paraparesis (hereafter referred to as HTLV-I–associated myelopathy).^1,2,3,4,5 HTVL-I is endemic in Japan, the Caribbean, Africa, and South America.⁵ Risk factors for infection include sexual contact, exchange of blood products, and vertical transmission from mother to child.⁵ HTLV-I–associated myelopathy causes progressive myelopathy with atrophy of the spinal cord.^5,6 Subcortical white-matter lesions are sometimes present on magnetic resonance imaging.^5,6,7 Cerebrospinal fluid shows pleocytosis, elevated titers of IgG, and oligoclonal bands.^8,9,10 Autopsy results correlate with neurologic findings and show spinal cord . . . [Full Text of this Article]

Case Report

Methods

Immunocytochemical Analysis

PCR

Cell Culture

Cytotoxic T-Lymphocyte Assays

Flow Cytometry

Results

Discussion

Source Information

From the Viral Immunology Section, Neuroimmunology Branch, National Institutes of Health (M.C.L., T.J.L., A.N.F., H.F.M., S.J.); the Neurosurgery Branch (J.D.H.) and the Office of the Clinical Director (D.K.), National Institute of Neurological Diseases and Stroke; and the Departments of Hematopathology (D.W.K., E.S.J.) and Neuroradiology (N.P.), National Cancer Institute — all in Bethesda, Md.

Address reprint requests to Dr. Jacobson at the Neuroimmunology Branch, NIH/NINDS, 10 Center Dr., Bldg. 10, Rm. 5B-16, Bethesda, MD 20892.

References

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• Umehara, F., Nagatomo, S., Yoshishige, K., Saito, M., Furukawa, Y., Usuku, K., Osame, M. (2004). Chronic progressive cervical myelopathy with HTLV-I infection: Variant form of HAM/TSP?. Neurology 63: 1276-1280 [Abstract] [Full Text]  
• Ozden, S., Cochet, M., Mikol, J., Teixeira, A., Gessain, A., Pique, C. (2004). Direct Evidence for a Chronic CD8+-T-Cell-Mediated Immune Reaction to Tax within the Muscle of a Human T-Cell Leukemia/Lymphoma Virus Type 1-Infected Patient with Sporadic Inclusion Body Myositis. J. Virol. 78: 10320-10327 [Abstract] [Full Text]  
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• Kubota, R., Furukawa, Y., Izumo, S., Usuku, K., Osame, M. (2003). Degenerate specificity of HTLV-1-specific CD8+ T cells during viral replication in patients with HTLV-1-associated myelopathy (HAM/TSP). Blood 101: 3074-3081 [Abstract] [Full Text]  
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• Kubota, R., Kawanishi, T., Matsubara, H., Manns, A., Jacobson, S. (1998). Demonstration of Human T Lymphotropic Virus Type I (HTLV-I) Tax-Specific CD8+ Lymphocytes Directly in Peripheral Blood of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis Patients by Intracellular Cytokine Detection. J. Immunol. 161: 482-488 [Abstract] [Full Text]  
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• Reddy, T. R., Li, X., Jones, Y., Ellisman, M. H., Ching, G. Y., Liem, R. K. H., Wong-Staal, F. (1998). Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein. Proc. Natl. Acad. Sci. USA 95: 702-707 [Abstract] [Full Text]