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Previous Volume 336:872-873 March 20, 1997 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Chambers et al. (Oct. 3 issue)¹ report birth outcomes after prenatal exposure to fluoxetine but fail to provide results for infants of mothers with mood disorders who were not treated or who received other antidepressant drugs. Although their findings of similar rates of major malformations in fluoxetine-exposed infants and unexposed infants are consistent with previous reports,² the findings of higher rates of perinatal complications after third-trimester exposure to fluoxetine are not.³

The authors propose that the occurrence of three minor malformations in a single infant is a marker for embryonic disruption and, specifically, central nervous system disruption. . . . [Full Text of this Article]

References

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• Hemels, M. E., Einarson, A., Koren, G., Lanctot, K. L, Einarson, T. R (2005). Antidepressant Use During Pregnancy and the Rates of Spontaneous Abortions: A Meta-Analysis. The Annals of Pharmacotherapy 39: 803-809 [Abstract] [Full Text]  
• Costa, L. G., Steardo, L., Cuomo, V. (2004). Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects. Pharmacol. Rev. 56: 103-147 [Abstract] [Full Text]