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Previous Volume 336:873-875 March 20, 1997 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hsich et al. (Sept. 26 issue)¹ described a new premortem diagnostic test for Creutzfeldt–Jakob disease and the related transmissible spongiform encephalopathies that consists of an immunoassay for the detection of the 14-3-3 brain protein in cerebrospinal fluid. They found that this procedure had a specificity of 99 percent and a sensitivity of 96 percent for the detection of Creutzfeldt–Jakob disease among patients with dementia who had not had a stroke within one month before testing. The authors concluded that their immunoassay "can . . . be widely used to establish the diagnosis of transmissible spongiform encephalopathy in . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Burkhard, P. R., Sanchez PhD, J.-C., Landis, T., Hochstrasser, D. F. (2001). CSF detection of the 14-3-3 protein in unselected patients with dementia. Neurology 56: 1528-1533 [Abstract] [Full Text]  
• Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey-Bloom, J., Relkin, N., Small, G. W., Miller, B., Stevens, J. C. (2001). Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56: 1143-1153 [Abstract] [Full Text]  
• Otto, M., Wiltfang, J., Schütz, E., Zerr, I., Otto, A., Pfahlberg, A., Gefeller, O., Uhr, M., Giese, A., Weber, T., Kretzschmar, H. A, Poser, S. (1998). Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study. BMJ 316: 577-582 [Abstract] [Full Text]