Despite impressive advances in the safety of the blood supply,1the search for therapeutic alternatives to blood continues.2,3Erythropoietin (along with iron, vitamin B12, and folic acid)has been recommended as a specific medication "that should beused instead of blood transfusion if the clinical conditionof the patient permits sufficient time for these agents to promoteerythropoiesis."4 Therapy with recombinant human erythropoietin(Epogen, Amgen, Thousand Oaks, Calif.) was first shown to correctthe anemia caused by chronic renal failure in patients undergoingdialysis.5 Subsequently, erythropoietin (Procrit, OrthoBiotech,Raritan, N.J.) was also approved for the treatment of anemiacaused . . . [Full Text of this Article]
Facilitating the Procurement of Autologous Blood
Erythropoietin
Acute Normovolemic Hemodilution
Combination Therapy
Stimulation of Erythropoiesis without Autologous Blood Donation
Dosage and Cost of Erythropoietin
Improving Cost Effectiveness
Predicting Perioperative Blood Requirements
Conclusions
Source Information
From the Departments of Medicine and Pathology (L.T.G.), Anesthesia (T.G.M.), and Surgery (G.L.A.), Washington University School of Medicine, St. Louis.
Address reprint requests to Dr. Goodnough at the Division of Laboratory Medicine, Box 8118, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.
References
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