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Volume 336:962-963 March 27, 1997 Number 13
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Pharmacologic Treatment of Cancer Pain

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 by Levy, M. H.
To the Editor: In his review of the treatment of cancer pain (Oct. 10 issue),1 Levy states that methadone is not recommended for routine (or initial) therapy. He goes on to state that an oral dose of 10 mg of methadone every six to eight hours is equivalent to 15 mg of morphine every four hours (Table 2 of the article). According to these recommendations, a patient receiving 150 mg of morphine every four hours would be switched to 100 mg of methadone every six to eight hours. This dose of methadone could result in severe sedation or respiratory depression . . . [Full Text of this Article]

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