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Previous Volume 336:1028-1029 April 3, 1997 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: It has been claimed that melatonin has many actions, mostly on the basis of uncontrolled studies of widely varying oral doses. It is commonly assumed that the administered dosage of melatonin bears a direct relation to its circulating concentration.

We estimated the bioavailability of oral melatonin by determining the pharmacokinetics of intravenous bolus and oral doses of melatonin (Sigma Chemical, St. Louis) in four normal men (21 to 32 years old), who were given 20 µg intravenously on one occasion and 500 µg orally on a second occasion, with an interval of at least one month between . . . [Full Text of this Article]

References

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• Shamseer, L., Vohra, S. (2009). Complementary, Holistic, and Integrative Medicine: Melatonin. Pediatr. Rev. 30: 223-228 [Full Text]  
• Naguib, M., Goldstein, P. A. (2009). All Results Count. Anesth. Analg. 108: 1058-1061 [Full Text]  
• Markantonis, S. L., Tsakalozou, E., Paraskeva, A., Staikou, C., Fassoulaki, A. (2008). Melatonin Pharmacokinetics in Premenopausal and Postmenopausal Healthy Female Volunteers. J Clin Pharmacol 48: 240-245 [Full Text]  
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• Kovács, J., Brodner, W., Kirchlechner, V., Arif, T., Waldhauser, F. (2000). Measurement of Urinary Melatonin: A Useful Tool for Monitoring Serum Melatonin after Its Oral Administration. J. Clin. Endocrinol. Metab. 85: 666-670 [Abstract] [Full Text]