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Previous Volume 336:1066-1071 April 10, 1997 Number 15 Next

Nuclear Factor-B — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

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In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the inflammatory state.¹ These activated cells produce many other mediators of inflammation.

What causes these diseases is still a mystery, but the disease process results from an interplay of genetic and environmental factors. Genes, such as those for atopy in asthma and for HLA antigens in rheumatoid arthritis and inflammatory bowel disease, may determine a patient's susceptibility to the disease and the disease's severity, but environmental factors, often unknown, . . . [Full Text of this Article]

NF-B

The Role of NF-B in Inflammatory Diseases

Effects of Glucocorticoids on NF-B

Therapeutic Implications

Source Information

From the Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London (P.J.B.); and the Department of Pharmacology, University of California at San Diego, La Jolla (M.K.).

Address reprint requests to Dr. Barnes at the Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St., London SW3 6LY, United Kingdom.

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