FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 336:1156-1162 April 17, 1997 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Acne vulgaris, or acne, as it is generally called, is the most common skin disease, affecting nearly 80 percent of persons at some time between the ages of 11 and 30 years.¹ It can persist for years and result in disfigurement and permanent scarring, and it can have serious adverse effects on psychosocial development, resulting in emotional problems, withdrawal from society, and depression.² The pathogenesis of acne is multifactorial, and therapy can now be directed at many of these factors. This review summarizes current concepts of the rational treatment of acne vulgaris.

Pathophysiology of Acne

Acne vulgaris is the result of the obstruction . . . [Full Text of this Article]

Therapies for Acne

Reduction of Sebum Production

Reduction of Epithelial Desquamation in Sebaceous Follicles

Prevention of Proliferation of P. acnes

Therapeutic Decisions

Comedonal Acne

Mild Inflammatory Acne

Inflammatory Acne

Conclusions

Source Information

From the Department of Dermatology, University of Pennsylvania School of Medicine, and Hospital of the University of Pennsylvania, 226 Rhoads Pavilion, 3400 Spruce St., Philadelphia, PA 19104-4283, where reprint requests should be addressed to Dr. Leyden.

References

This article has been cited by other articles:

• Van, Y.-H., Lee, W.-H., Ortiz, S., Lee, M.-H., Qin, H.-J., Liu, C.-P. (2009). All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-{gamma}-Producing T-cells Without Affecting Th17 Cells. Diabetes 58: 146-155 [Abstract] [Full Text]  
• Zaenglein, A. L., Thiboutot, D. M. (2006). Expert Committee Recommendations for Acne Management. Pediatrics 118: 1188-1199 [Abstract] [Full Text]  
• (2003). Acne, isotretinoin and depression. DTB 41: 76-78 [Abstract] [Full Text]  
• Levy, R. M., Huang, E. Y., Roling, D., Leyden, J. J., Margolis, D. J. (2003). Effect of Antibiotics on the Oropharyngeal Flora in Patients With Acne. Arch Dermatol 139: 467-471 [Abstract] [Full Text]  
• Giltay, E. J., Gooren, L. J. G. (2000). Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females. J. Clin. Endocrinol. Metab. 85: 2913-2921 [Abstract] [Full Text]  
• Thiboutot, D. (2000). New Treatments and Therapeutic Strategies for Acne. Arch Fam Med 9: 179-187 [Abstract] [Full Text]