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Previous Volume 336:1189-1190 April 17, 1997 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Postpartum depression occurs in approximately 10 percent of women who give birth and is associated with substantial morbidity in mothers and their children. For some women, treatment with an antidepressant drug may be necessary but complicated by their desire to continue to breast-feed. Unfortunately, there is a dearth of information on the safety of treatment with various antidepressant drugs, including the selective serotonin-reuptake inhibitors, during breast-feeding. During gestation, serotonin (5-hydroxytryptamine) influences neurogenesis and morphogenesis, and in the neonatal period it modulates synaptogenesis.¹ The effects of 5-hydroxytryptamine on early neurodevelopment arouse special concern about the use of selective . . . [Full Text of this Article]

References

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• Epperson, C. N., Jatlow, P. I., Czarkowski, K., Anderson, G. M. (2003). Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs. Pediatrics 112: e425-425 [Abstract] [Full Text]  
• Epperson, N., Czarkowski, K. A., Ward-O'Brien, D., Weiss, E., Gueorguieva, R., Jatlow, P., Anderson, G. M. (2001). Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs. Am. J. Psychiatry 158: 1631-1637 [Abstract] [Full Text]  
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• Ito, S. (2000). Drug Therapy for Breast-Feeding Women. NEJM 343: 118-126 [Full Text]  
• LONGHURST, J. G., WEISS, E. (1998). Use of Psychotropic Medications During Lactation. Am. J. Psychiatry 155: 1626a-1626 [Full Text]  
• STOWE, Z. N., OWENS, M. J. (1998). Drs. Stowe and Owens Reply. Am. J. Psychiatry 155: 1626a-1626 [Full Text]  
• Wisner, K. L., Perel, J. M., Blumer, J. (1998). Serum Sertraline and N-Desmethylsertraline Levels in Breast-Feeding Mother-Infant Pairs. Am. J. Psychiatry 155: 690-692 [Abstract] [Full Text]