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Correspondence
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Volume 336:1324-1325 May 1, 1997 Number 18
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Valvular Heart Disease and Systemic Lupus Erythematosus

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 by Roldan, C. A.
To the Editor: The article by Roldan et al. on valvular heart disease associated with systemic lupus erythematosus (Nov. 7 issue)1 prompts two remarks. First, the authors did not give any data on antiphospholipid antibodies. There are at least five studies showing an association between the presence of antiphospholipid antibodies and valvular heart disease in patients with lupus.2 Furthermore, antiphospholipid antibodies have been detected in heart-valve lesions, suggesting a causative role of these antibodies.3 The close association of antiphospholipid antibodies with thrombotic events has shed light on the focal neurologic manifestations of lupus. Indeed, these manifestations, previously assumed to result . . . [Full Text of this Article]

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