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Previous Volume 336:1365-1372 May 8, 1997 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Plastic anemia, which is pancytopenia with a fatty or "empty" bone marrow, is remarkable for the simplicity of its pathologic picture and the direct derivation of its clinical manifestations.¹ Although it is not a common disease, the drama of an individual case and the larger consequences of its associations give it considerable interest. That aplastic anemia is perhaps the most dreaded idiosyncratic complication of drug treatment has serious and often expensive consequences for drug development, for risk assessment, for approval by regulatory agencies, and in legal actions.

Aplastic anemia, first described by Paul Ehrlich in 1888 from an autopsy of . . . [Full Text of this Article]

Hematopoiesis in Bone Marrow Failure

Stem Cells

Stroma and Hematopoietic Growth Factors

Medical Therapy and Inferences about the Mechanism of Disease

Direct Hematopoietic Injury

Immune-Mediated Bone Marrow Failure

Immune Destruction of Hematopoietic Cells

Inciting Events

Hepatitis, Aplastic Anemia, and Viruses

Drugs as Antigens

Relation to Late Clonal Hematologic Disorders

Aplastic Anemia and Other Immune-Mediated Diseases

Source Information

From the Hematology Branch, National Heart, Lung, and Blood Institute, Bldg. 10, Rm. 7C103, NIH, 9000 Rockville Pike, Bethesda, MD 20892-1652, where reprint requests should be addressed to Dr. Young.

References

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