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Previous Volume 336:106-109 January 9, 1997 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1945 Gamble et al.¹ and Darrow² reported on two infants with severe congenital diarrhea, in back-to-back articles with identical titles. Both infants had very high stool chloride concentrations, low urinary chloride excretion, hypochloremia, metabolic alkalosis, and hypokalemia. Gamble et al. concluded that the disease was caused by abnormal secretion of chloride into the intestine, and they named it congenital alkalosis with diarrhea. Darrow believed that the primary defect was intestinal chloride malabsorption, but he gave much of the credit for characterizing the disorder to Gamble et al. and used the name they had chosen.

Subsequent studies supported Darrow's belief . . . [Full Text of this Article]

Case Report

Results

Discussion

Source Information

From the Department of Internal Medicine, Baylor University Medical Center, Dallas (B.W.A., C.A.S.A., J.L.P., J.S.F.), and the Columbia Independence Regional Health Center, Independence, Mo. (C.H.Z.).

Address reprint requests to Dr. Fordtran at Baylor University Medical Center, GI Research, 3500 Gaston Ave., Dallas, TX 75246.

References

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• Gennari, F. J., Weise, W. J. (2008). Acid-Base Disturbances in Gastrointestinal Disease. CJASN 3: 1861-1868 [Abstract] [Full Text]  
• Pecache, N, Patole, S, Hagan, R, Hill, D, Charles, A, Papadimitriou, J M (2004). Neonatal congenital microvillus atrophy. Postgrad. Med. J. 80: 80-83 [Abstract] [Full Text]  
• Chernova, M. N, Jiang, L., Shmukler, B. E, Schweinfest, C. W, Blanco, P., Freedman, S. D, Stewart, A. K, Alper, S. L (2003). Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J. Physiol. 549: 3-19 [Abstract] [Full Text]  
• Bieringer, M., Kettritz, R. (2003). A wretching business: 'how to get the most out of the numbers'. Nephrol Dial Transplant 18: 836-839 [Full Text]  
• Hoglund, P, Holmberg, C, Sherman, P, Kere, J (2001). Distinct outcomes of chloride diarrhoea in two siblings with identical genetic background of the disease: implications for early diagnosis and treatment. Gut 48: 724-727 [Abstract] [Full Text]  
• GALLA, J. H. (2000). Metabolic Alkalosis. J. Am. Soc. Nephrol. 11: 369-375 [Full Text]  
• Everett, L. A., Green, EricD. (1999). A family of mammalian anion transportersand their involvement in human genetic diseases. Hum Mol Genet 8: 1883-1891 [Abstract] [Full Text]