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Correspondence
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Volume 336:1452-1454 May 15, 1997 Number 20
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Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery

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 by Mangano, D. T.
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To the Editor: Dr. Mangano and other investigators in the Multicenter Study of Perioperative Ischemia Research Group (Dec. 5 issue)1 have failed to report directly the outcome of the eight patients in the placebo group who were taking beta-blockers preoperatively. There were 12 deaths from cardiac causes in the placebo group. If all eight patients who were taking beta-blockers preoperatively died from cardiac events, then what the authors have really found is that the sudden perioperative withdrawal of beta-blockers is deleterious. This is quite possible, given the well-supported position, which the authors promote, that the effects of tachycardia and hypertension . . . [Full Text of this Article]

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