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Editorial
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Volume 336:1599-1600 May 29, 1997 Number 22
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Ion Channels — Molecular Divining Rods Hit Their Clinical Mark

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Two interesting papers on ion channels appear in this issue of the Journal. In the first, Splawski et al.1 describe the clinical manifestations of a mutation in an ion-channel gene in an extended family. A young girl with congenital hearing loss and severe cardiac dysrhythmia was found to have lost a specific potassium channel (she was homozygous for mutations in KVLQT1), whereas many of her family members had mild prolongation of the QT interval on the electrocardiogram and were heterozygous carriers of the same mutant gene. In the second article, Ackerman and Clapham2 provide a review of ion-channel structure . . . [Full Text of this Article]

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