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The antiphospholipid-antibody syndrome is enigmatic for several reasons. Until recently, there was no standardized definition of the syndrome. The associated antibodies (lupus anticoagulant and anticardiolipin antibody) can come and go in a given patient, and experts differ about which tests should be performed. It is clear that the antibodies are associated with clinical complications such as thromboembolism, thrombocytopenia, and loss of pregnancy, but it is unclear whether the antibodies actually cause these complications. Most daunting for clinicians is the paucity of controlled clinical trials of treatments for the syndrome.
The editors have assembled a group of internationally recognized authors, who
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