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Previous Volume 336:1802-1811 June 19, 1997 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The inability to consume enough calories to meet energy requirements is a common threat to survival. To meet this danger, animals retard their fuel depletion by lowering their metabolic rate and changing fuel substrates. They also stimulate their feeding behavior and defer the high energy cost of reproduction by suppressing gonadal function. We are now beginning to understand the physiologic basis of these responses.

Historical Background

Early investigators^1,2 established that after the first few days of starvation, free fatty acids and ketone bodies, rather than glucose, become the predominant fuels. The adaptive value of this switch derives from the limited supply of . . . [Full Text of this Article]

Negative-Feedback Regulation of Body Adiposity

Neuropeptide Y

Consequences of Genetic Neuropeptide Y Deficiency

The HPA Axis during Starvation

Catabolic Hypothalamic Pathways in Energy Homeostasis

Clinical Applications

Active Weight Reduction as Compared with the Maintenance of Stable, Reduced Weight

Leptin Deficiency and Endocrine Disorders

Diabetes Mellitus

Adrenal Disorders and the Role of Glucocorticoids

Wasting Illness

Summary and Conclusions

Discussion

Source Information

From the Departments of Medicine (M.W.S.) and Psychology (R.J.S.), University of Washington, Harborview Medical Center, and Veterans Affairs Puget Sound Health Care System — all in Seattle.

Address reprint requests to Dr. Schwartz at Metabolism (151), VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108.

References

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