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Previous Volume 336:215-217 January 16, 1997 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The proximate cause of the clinical manifestations of Cushing's syndrome — obesity, facial plethora, hirsutism, hypertension, muscle weakness, lethargy, and depression — is excess cortisol secretion. Few of these clinical manifestations are specific to the syndrome, but the presence of several of them should lead clinicians to suspect it (and when many are present, the changes may be dramatic). The next steps are to confirm the presence of cortisol excess and then to determine its cause.

The predominant causes of Cushing's syndrome are excess corticotropin secretion, whether from a pituitary tumor (Cushing's disease) or a nonendocrine tumor, and adrenal tumors, . . . [Full Text of this Article]

References

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• Fernandez, A., Brada, M., Zabuliene, L., Karavitaki, N., Wass, J. A H (2009). Radiation-induced hypopituitarism. Endocr Relat Cancer 16: 733-772 [Abstract] [Full Text]  
• Pluta, R. M., Nieman, L., Doppman, J. L., Watson, J. C., Tresser, N., Katz, D. A., Oldfield, E. H. (1999). Extrapituitary Parasellar Microadenoma in Cushing's Disease. J. Clin. Endocrinol. Metab. 84: 2912-2923 [Abstract] [Full Text]